Proton pump inhibitors and the risk of colorectal cancer: a systematic review and meta-analysis of observational studies

The increased risk of colorectal cancer (CRC) associated with long-term use of proton pump inhibitors (PPIs) has attracted considerable attention; however, the conclusions of studies evaluating this correlation are inconsistent or even controversial. Therefore, we conducted a systematic review and meta-analysis to determine the association of PPI use with the risk of CRC. A systematic literature search was conducted in PubMed, EMBASE, and the...