Abstract Wound management has attracted significant interest in view of the broad demand market. Dressings are playing crucial roles in wounds management because they can protect the wound from external infection, and accelerate the healing process. Among the various available dressing materials, hydrogels have appealed increasing attention for their tunable chemical, physical and biological properties, and three-dimensional cross-linked polymer networks which can absorb and retain large amount of water. Although hydrogels have become representative of soft dressing materials, the design of conventional hydrogel materials still needs improvement. Nowadays, novel self-healing hydrogel wound dressings hopefully optimize the defects of mechanical property over conventional hydrogel thus extend their usage lifespan due to their potential of autonomous self-recovery against damage, which have gained much momentum recently. This presented review mainly focuses on research status of self-healing hydrogel for wound management. The polymers suitable for hydrogel forming, and the appropriate molecular design of the hydrogel network for achieving self-healing properties are discussed, followed by the applications of self-healing hydrogel as wound dressing. Finally, we discuss the future perspectives of self-healing hydrogel as wound dressing, and provide the recommendations for its possible developing orientation.
Last. Ya Liu(Ocean University of China)H-Index: 21
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Marine-derived chitosan has been widely examined for its use in developing biomedical materials. Not only is it non-toxic, biocompatible, and degradable, it has also shown unique antimicrobial properties. The antimicrobial properties of chitosan are restricted by neutral and physiological conditions because it is insoluble in water and its pKa values is 6.5. One solution to this problem is to graft chemically modified groups onto the backbone of chitosan. The aim of this paper is to review the m...
Last. Baolin Guo(Xi'an Jiaotong University)H-Index: 57
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Abstract Bacteria-infected wounds and antibiotics abuse have become significant burdens to patients and medical systems. Thus, designing a non-antibiotic-dependent multifunctional wound dressing for treating bacteria-infected wounds is urgently desired. Herein, a series of conductive self-healing and adhesive nanocomposite hydrogels with a remarkable photothermal antibacterial property based on N-carboxyethyl chitosan (CEC) and benzaldehyde-terminated Pluronic F127/carbon nanotubes (PF127/CNT) w...
Last. Baolin Guo(Xi'an Jiaotong University)H-Index: 57
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As the abuse of antibiotics continues to increase, the emergence of antibiotic resistance and unknown drug-resistant bacterial infections pose a great threat on people worldwide. In this work, we a...
Self-healing injectable hydrogel biomaterials uniquely enable precise therapeutic deposition and deployment at specific bodily locations through versatile and minimally invasive processes that can preserve cargo integrity and cell viability. Despite the distinct advantages that injectable hydrogels offer in tissue engineering and therapeutic delivery, exceptionally few have been created using components naturally present in the cellular niche. In this work, we introduce a shear-thinning hydrogel...
Abstract Inspired by the adhesion mechanism of natural mussels, polydopamine (PDA) has been widely studied and applied in hydrogels due to its good adhesion to various materials. In this work, a double-layer hydrogel constituted of an adhesive layer and a tough layer was successfully prepared via in-situ polymerization. Adding polystyrene particles into the tough layer could improve the mechanical properties, and the adhesion of various substrates could be achieved with PDA nanoparticles in the ...
Abstract Wound healing is a dynamic and complex process which affects the quality of life in patients and annually causes high costs for the health system, worldwide. Polymers from natural origins such as polysaccharides have gained particular interest between researchers for wound dressing applications due to their abundance in nature, biocompatibility with human tissues, and ideal physicochemical properties. Aside from their supportive effect in wound care, polysaccharides and their derivative...
An ideal wound dressing is highly desired for the repair of chronic wounds which should provide a moist environment, self-healing, antibacterial properties etc. Here, a novel injectable antibacterial chitosan hydrogel with good self-healing and improved mechanical properties has been prepared by dialdehyde bacterial cellulose (DABC) nanofibers as the non-toxic biocrosslinker. It is the first time to prepare the all-natural chitosan hydrogels by using ascorbic acid (VC) as solvent to dissolve chi...
Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the na...
#1Wenyu Wang(WMU: Weifang Medical University)H-Index: 1
#2Dejun Ding(WMU: Weifang Medical University)H-Index: 14
Last. Cheng Ni(WMU: Weifang Medical University)H-Index: 1
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ABSTRACT Nitric oxide (NO) has emerged as a potential wound therapeutic agent due to its pivotal role in the wound healing processes. Nevertheless, NO-based therapy for clinical applications is still restricted due to its gaseous state and short half-life. Here we exploited a wound dressing by incorporating sodium nitroprusside doped prussian blue nanoparticals and Type I collagen into the chitosan/poly(vinyl alcohol) nanofibers through the electrospinning method. This hybrid nanofibrous scaffol...
Last. Baowei Su(MOE: Chinese Ministry of Education)H-Index: 16
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Abstract null null Reverse osmosis (RO) is widely used in water purification process. However, most commercial RO membranes have low water permeance, and encounter a “trade-off” effect between permeance and rejection. In this work, a kind of RO membrane with an in-situ formed film of sodium alginate (SA) hydrogel as an interlayer on the surface of a polysulfone (PSf) substrate has been extensively investigated. The SA hydrogel interlayer significantly controls and reduces the diffusion rate of t...
Last. Aniruddha Roy(BITS: Birla Institute of Technology and Science)H-Index: 13
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Abstract null null The importance of the extra-cellular matrix (ECM) for wound healing has been extensively researched. Understanding its importance, multiple ECM mimetic scaffolds have been developed. However, the majority of such scaffolds are prefabricated. Due to their stiffness, prefabricated scaffolds cannot come into direct contact with the basal skin cells at the wound bed, limiting their efficacy. We have developed a unique wound dressing, using chitosan (CH) and chondroitin sulfate (CS...
Last. Qilin Huang(HAU: Huazhong Agricultural University)H-Index: 12
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Abstract This work investigated the self-healing properties of Lignosus rhinocerotis polysaccharide (LRP) and the effect of temperature on its rheological behavior. Dynamic sweep tests (strain sweep, frequency sweep, and time sweep) showed that the LRP/water system possessed self-healing properties due to the entangled network formed by hyperbranched LRP molecular chains. The flow activation energy of LRP solution calculated by Arrhenius equation was shown to decrease with increasing LRP concent...
Self-healing hydrogels have been paid growing attention in biomedical applications. The abundance, biocompatibility, biodegradability, antibacterial activity and amino groups’ reactivity make chitosan suitable for constructing autonomously self-healable hydrogels for biomedical applications. In this article, the recent development of chitosan-based self-healing hydrogels has been summarized and discussed. Based on the reversible linkages, either Schiff-base or physical interactions, the reported...
Abstract A hydrogel containing exocellular (1 → 6)-β-D-glucan (lasiodiplodan, LAS) was developed and its wound healing potential was evaluated. β-Glucans have attracted much interest by the cosmetic industry sector because of their bioactive and functional properties and in promoting skin health. In the present study an β-glucan was studied as a healing biomaterial that has not hitherto been reported in the scientific literature. LAS produced by the ascomycete Lasiodiplodia theobromae MMPI was u...
Skin wounds are damage to the epithelial layer and the integrity of living tissue. The healing mechanism is dynamic and complex, and often treatments with wound dressings help in tissue regeneration, reducing the risk of infections. Polymeric hydrogels become good candidates for wet curing process. These materials prevent dehydration of the tissue and avoid discomfort to the patient when changing the dressing. In this short review, we demonstrate the importance of the healing process, the types ...
Last. Ya Liu(Ocean University of China)H-Index: 21
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Acute and chronic wounds can cause severe physical trauma to patients and also result in an immense socio-economic burden. Thus, wound management has attracted increasing attention in recent years. However, burn wound management is still a major challenge in wound management. Autografts are often considered the gold-standard for burn care, but their application is limited by many factors. Hence, ideal burn dressings and skin substitute dressings are desirable. With the development of biomaterial...