Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression
Abstract
Increasing studies confirm that anti-angiogenesis can increase the effectiveness of immunotherapy. In this study, we found that an angiogenesis inhibitor apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression. Apatinib treatment upregulated PD-L1 expression in various colon cancer cells both at the mRNA and protein levels. Further, apatinib-treated cancer cells hampered activation and IFN-γ secretion of T...
Paper Details
Title
Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression
Published Date
Nov 1, 2020
Volume
88
Pages
106858 - 106858
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