International Immunopharmacology
Papers 8,070
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#2Qin Li (Yunnan University)
Last. Chun-Ping Wan (Yunnan University)H-Index: 2
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Abstract null null Backgrounds null To date, the effects of SARS-CoV-2 vaccines on people living with HIV (PLWH) were mainly focused on messenger RNA (mRNA) and adenovirus vector-based vaccines, and little is known about the effects of inactivated virus-based vaccine. This study was designed to determine the effects of inactivated SARS-CoV-2 vaccines on PLWH. null null null Methods null Twenty-four HIV-positive individuals and 24 healthy donors (HD) were respectively recruited from Malipo Countr...
#1Peng Zhao (Henan University)H-Index: 8
#2Zehui Cai (Henan University)
Last. Jiansheng Li (Henan University)H-Index: 10
view all 8 authors...
Abstract null null Background and purpose null The M2 polarization of macrophages substantially contributes to the progression of pulmonary fibrosis (PF). Effective-compound combination (ECC), which is composed of isoliquiritigenin, icariin, nobiletin, peimine, and paeoniflorin, ameliorated bleomycin-induced PF in rats. Hence, we investigated the anti-PF mechanism of ECC with a focus on the suppression of M2 polarization in macrophages in vivo and in vitro. null null null Methods null The PF rat...
#1Ling Xie (Tongji University)H-Index: 1
#2Kaidireya Saimaier (Tongji University)
Last. Changsheng Du (Tongji University)H-Index: 11
view all 9 authors...
Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) mediated by immune cells. The pathogenesis of most autoimmune diseases has some degree of similarity to that of MS, and therefore the study of MS has clinical and scientific significance for other autoimmune diseases as well. As a widely used organic solvent, Methyl Acetate (MA) has a similar structure to acetate which has been shown to be therapeutic in the mouse model of multiple sclerosis. Here w...
#1Qi Wang (XJTU: Xi'an Jiaotong University)
#2Yun Xie (XJTU: Xi'an Jiaotong University)
Last. Jiru Xu (XJTU: Xi'an Jiaotong University)
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LncRNA-Cox2 has been reported to regulate macrophage polarization, and the activation of macrophages is a major participant in the pathogenesis of sepsis. Therefore, we explored whether lncRNA-Cox2 was involved in the progression of sepsis. In this study, we established a cecal ligation and puncture (CLP) mouse model and found that silencing lncRNA-Cox2 in CLP mice improved the 7-day survival rate, and alleviated the increase of blood bacterial burdens, systemic inflammatory response, and pulmon...
#1Chaoqi Zhang (Zhengzhou University)H-Index: 16
#2Zhen Zhang (Zhengzhou University)H-Index: 20
Last. Yi Zhang (Zhengzhou University)H-Index: 116
view all 13 authors...
#1Ming Li (NAU: Nanjing Agricultural University)H-Index: 1
#2Zhenglei Wang (NAU: Nanjing Agricultural University)H-Index: 4
Last. Jinfeng Miao (NAU: Nanjing Agricultural University)H-Index: 11
view all 8 authors...
Streptococcus uberis (S. uberis) is an important causative agent of mastitis, leading to significant economic losses to dairy industry. This research used a mouse mastitis model to investigate the protective effects of taurine on mammary inflammatory response and blood-milk barrier integrity in S. uberis challenge. The results showed that taurine attenuated S. uberis-induced mammary histopathological changes, especially neutrophil infiltration. The S. uberis-induced expression of pro-inflammator...
#1Wei-wei Li (ZMU: Zunyi Medical University)
#2Dan Li (ZMU: Zunyi Medical University)H-Index: 3
Last. Gang Wang (ZMU: Zunyi Medical University)H-Index: 3
view all 11 authors...
Abstract null null Inflammation modulation is currently considered a promising therapeutic strategy to counteract the burden of cardiovascular disease. Amentoflavone (AME) is a natural biflavone with two apigenin molecules that, possess promising anti-inflammatory, anti-oxidative, and anti-cancer properties. In the present study, we aimed to investigate the effects of AME on myocardial ischemia-reperfusion injury in vivo and in vitro, and to elucidate the underlying mechanism. Our results showed...
#1Zaoqu Liu (Zhengzhou University)H-Index: 6
#2Long Liu (Zhengzhou University)H-Index: 5
Last. Xinwei Han (Zhengzhou University)H-Index: 22
view all 7 authors...
Abstract null null Introduction null The tumor microenvironment (TME) has profound impacts on prognosis and immunotherapy. The TME can be altered by the genomic mutations on specific tumor-suppressor genes (TSG), thus, comprehending the association between TME and TSG in hepatocellular carcinoma (HCC) is imperative. null null null Methods null With a total of 1699 HCC patients from 6 international multicenter cohorts, we delineated the mutational landscape of TSG and summarized the proportion of...
#1Mengmeng Jiang (UM: University of Macau)H-Index: 2
#2Jia Liu (Changchun University)
Last. Xin Chen (UM: University of Macau)H-Index: 38
view all 10 authors...
Abstract null null Immunosuppressive CD4+Foxp3+ regulatory T cells (Tregs) promote tumor immune evasion and thus targeting of Tregs has become an strategy in cancer immunotherapy. Tumor necrosis factor receptor 2 (TNFR2) is highly expressed and important for the immunosuppressive function of Tregs in humans and mice. Thus, the benefit of targeting TNFR2 in cancer immunotherapy merits more investigation. A previous report identified a new murine monoclonal anti-TNFR2 antibody (designated TY101), ...
#1Khadeja-Tul Kubra (University of Louisiana at Monroe)H-Index: 9
#2Mohammad A. Uddin (University of Louisiana at Monroe)H-Index: 13
Last. Nektarios Barabutis (University of Louisiana at Monroe)H-Index: 23
view all 6 authors...
Abstract null null The endothelial barrier regulates interstitial fluid homeostasis by transcellular and paracellular means. Dysregulation of this semipermeable barrier may lead to vascular leakage, edema, and accumulation of pro-inflammatory cytokines, inducing microvascular hyperpermeability. Investigating the molecular pathways involved in those events will most probably provide novel therapeutic possibilities in pathologies related to endothelial barrier dysfunction. Metformin (MET) is an an...
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