Multiple Parallel Hits Hypothesis in Nonalcoholic Fatty Liver Disease: Revisited After a Decade

Nonalcoholic fatty liver disease (NAFLD) is an epidemic liver disease, affecting approximately one quarter of the entire population in the world.(1) This disease encompasses a broad spectrum of clinical phenotypes ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH), fibrotic NASH, advanced fibrosis, liver cirrhosis, and hepatocellular carcinoma (HCC). Although liver inflammation in NAFLD appears less prognostically relevant...