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We read with interest the article by Jasper S. et al.(1) regarding toxin induced liver injury (TLI) after liver transplantation (LT) in yellow phosphorus (YP) poisoning. The authors postulate that early allograft dysfunction (EAD) is secondary to TLI from YP released from non-hepatic tissues after LT. We believe that there are theoretical and practical problems with this hypothesis.
Light chain deposition disease (LCDD) is a rare entity that is generally discovered in the setting of solid organ dysfunction. The monoclonal gammopathy leads to abnormal deposition of light chains in tissues, most often manifested by way of renal dysfunction. Other organ systems may also be affected, the liver being the second most common after the kidneys. Liver involvement rarely leads to clinically significant disease with few case reports in the literature. We present the case of a patient ...
#1Abdul Hakeem (Bharath University)H-Index: 11
#2Ashwin Rammohan (Bharath University)H-Index: 2
Last. Mohamed Rela (Bharath University)H-Index: 35
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We thank Varghese et al. for the interest shown in our article. Their assumptions are nonetheless fractious and factually erroneous, necessitating clarification. The findings of post-liver transplant (LT) allograft biopsies in our cohort of yellow phosphorus (YP) toxin-related liver injury (TLI) was unlike anything observed in other causes of post-LT early allograft dysfunction (EAD).
#1Komal Ramani (Cedars-Sinai Medical Center)H-Index: 15
#2Aaron E. Robinson (Stanford University)H-Index: 1
Last. Zehra Yildirim (Cedars-Sinai Medical Center)H-Index: 2
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BACKGROUND & AIMS Methionine adenosyltransferase 1A (MAT1A) is responsible for S-adenosylmethionine (SAMe) biosynthesis in the liver. Mice lacking Mat1a have hepatic SAMe depletion, develop non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) spontaneously. Several kinases are activated in Mat1a knockout (KO) mice livers. However, the phosphos-proteome has not been characterized and whether they contribute to liver pathology is largely unknown. Our study aimed to fill this gap...
#1Laurens A. van Kleef (EUR: Erasmus University Rotterdam)
#2Ibrahim Ayada (EUR: Erasmus University Rotterdam)
Last. Robert J. de Knegt (EUR: Erasmus University Rotterdam)H-Index: 34
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BACKGROUND & AIMS Recently metabolic dysfunction associated fatty liver disease (MAFLD) has been introduced and was defined as hepatic steatosis with either overweight, diabetes and/or a combination of other metabolic risk factors. We investigated the application of the novel MAFLD criteria as compared to non-alcoholic fatty liver disease (NAFLD). APPROACH & RESULTS We performed a cross-sectional analysis within The Rotterdam Study, a large prospective population-based cohort. Participants who a...
#1Adriana Psaraki (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Lydia Ntari (UoA: National and Kapodistrian University of Athens)
Last. Maria G. Roubelakis (UoA: National and Kapodistrian University of Athens)H-Index: 23
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BACKGROUND & AIMS Liver dysfunctions are classified into acute and chronic diseases, which comprise a heterogeneous group of pathological features and a high mortality rate. Liver transplantation still remains the gold standard therapy for most of liver diseases with concomitant limitations related to donor organ shortage and life-long immunosuppressive therapy. Novel concept in liver therapy intends to overcome these limitations based on the secreted extracellular vesicles (EVs; microvesicles a...
#1Linh Pham (IU: Indiana University)H-Index: 1
#2Lindsey Kennedy (Veterans Health Administration)H-Index: 10
Last. Ludovica Ceci (IU: Indiana University)H-Index: 3
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Mast cells (MCs) induce the progression of liver diseases including, but not limited to, hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), alcoholic and non-alcoholic fatty liver disease (ALD/NAFLD), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). The effects of MCs during disease progression includes alterations in ductular reaction, steatosis, hepatic fibrosis and inflammation. In addition, there is significant crosstalk between MCs, MC mediators (histamine...
#1Tao Lin (Heidelberg University)H-Index: 2
#2S Wang (Heidelberg University)H-Index: 2
Last. Chun-Lei Fan (Capital Medical University)H-Index: 6
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Background & aims null In patients with acute liver failure (ALF) who suffer from massive hepatocyte loss, liver progenitor cells (LPC) take over key hepatocyte functions, which ultimately determines survival. This study investigated how the expression of HNF4α, its regulators and targets in LPC determines clinical outcome of ALF patients. null Approach & results null Clinicopathological associations were scrutinized in 19 ALF patients (9 recovered and 10 receiving liver transplantation). Regula...
#1Hege Marie Vedeld (Oslo University Hospital)H-Index: 9
#2Marit Mæhle Grimsrud (Oslo University Hospital)H-Index: 4
Last. Annika Bergquist (Karolinska University Hospital)H-Index: 51
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BACKGROUND & AIMS Primary sclerosing cholangitis (PSC) is associated with increased risk of cholangiocarcinoma (CCA). Early and accurate CCA detection represents an unmet clinical need, as the majority of PSC patients are diagnosed at advanced stage of malignancy. In the present study, we aimed at establishing robust DNA methylation biomarkers in bile for early and accurate diagnosis of CCA in PSC. APPROACH & RESULTS Droplet digital PCR (ddPCR) was used to analyze 344 bile samples from 273 patie...
#1Jiajun Fu (WHU: Wuhan University)H-Index: 2
#2Fengjiao Hu (WHU: Wuhan University)H-Index: 1
Last. Chongshu Jian (WHU: Wuhan University)H-Index: 1
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BACKGROUND & AIMS Although the prevalence of nonalcoholic fatty liver disease (NAFLD) has risen dramatically to 25% of the adult population worldwide, there are as yet no approved pharmacological interventions for the disease due to uncertainty about the underlying molecular mechanisms. It is known that mitochondrial dysfunction is an important factor in the development of NAFLD. Mitochondrial antiviral signaling protein (MAVS) is a critical signaling adaptor for host defenses against viral infe...
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Diabetes mellitus