MiR-181c protects cardiomyocyte injury by preventing cell apoptosis through PI3K/Akt signaling pathway

Cardiomyocyte apoptosis plays an important role in the development of heart failure, which leads to high mortality in patients with cardiovascular diseases. In this study, we are focused to identify the role of miRNA-181c in the regulating of myocardial tissue apoptosis in the doxorubicin (DOX) or hypoxia/reoxygenation (H/R) induced H9C2 cardiomyocyte injury.DOX-induced heart failure animal model was established using mice. Total RNA was...