Xinchun Yang
Capital Medical University
Internal medicineEndocrinologyLogistic regressionOdds ratioCardiologyProspective cohort studyHeart failureAtrial fibrillationPercutaneous coronary interventionMaceIn patientConventional PCIMyocardial infarctionGut floraMedicineEjection fractionBlood pressureBiology
Publications 186
#1Ying Dong (Capital Medical University)
#2Pan Wang (Capital Medical University)H-Index: 5
Last. He Jiang (RUC: Renmin University of China)
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Study Objectives: Obstructive sleep apnea (OSA) is a clinical syndrome characterized by recurrent episodes of apnea or hypopnea of the upper airway, leading to increased negative intrathoracic pres...
#1Xiaoli Li (Capital Medical University)H-Index: 1
#2Zhen Zeng (THU: Tsinghua University)H-Index: 1
Last. Hongjiang Wang (Capital Medical University)H-Index: 4
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OBJECTIVE To evaluate the predictive value of CHADS2 and CHA2DS2-VASc scores for coronary artery lesions and in-hospital prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS A total of 524 patients who were diagnosed with STEMI from January 2016 to August 2017 were retrospectively reviewed. The correlation between CHADS2 and CHA2DS2-VASc scores with the patients' clinical data, number of coronary lesions, Gensini scores, the target vessel and hospitalizati...
#1Zheng Ma (Capital Medical University)H-Index: 2
#2Juan-Juan Song (Capital Medical University)H-Index: 3
Last. Jiuchang Zhong (Capital Medical University)H-Index: 4
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Heart failure (HF) is a growing epidemic with high morbidity and mortality at an international scale. The apelin-APJ receptor pathway has been implicated in HF, making it a promising therapeutic target. APJ has been shown to be activated by a novel endogenous peptide ligand known as Elabela (ELA, also called Toddler or Apela), with a critical role in cardiac development and function. Activation of the ELA-APJ receptor axis exerts a wide range of physiological effects, including depressor respons...
12 CitationsSource
#1Jing Zhang (Capital Medical University)H-Index: 1
#2Kun Zuo (Capital Medical University)H-Index: 5
Last. Xinchun Yang (Capital Medical University)H-Index: 18
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Background null The gut microbiota provides health benefits in humans by producing short-chain fatty acids (SCFAs), whose deficiency causes multiple disorders and inflammatory diseases. However, gut bacteria producing SCFAs in patients with atrial fibrillation (AF), an arrhythmia with increasing prevalence, have not been reported. To investigate major gut microbial organisms related to SCFA synthesis, SCFAs-associated KEGG orthologues (KOs), enzymatic genes, and potential producers were examined...
#1Juan-Juan Song (Capital Medical University)H-Index: 3
#2Mei Yang (Capital Medical University)H-Index: 1
Last. Qian Zhang (Capital Medical University)
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Apoptosis, inflammation, and fibrosis contribute to vascular remodeling and injury. Elabela (ELA) serves as a crucial regulator to maintain vascular function and has been implicated in the pathogenesis of hypertensive vascular remodeling. This study aims to explore regulatory roles and underlying mechanisms of ELA in rat aortic adventitial fibroblasts (AFs) in response to angiotensin II (ATII). In cultured AFs, exposure to ATII resulted in marked decreases in mRNA and protein levels of ELA, fibr...
#1Zheng Ma (Capital Medical University)H-Index: 2
#2Lei Zhao (Capital Medical University)H-Index: 8
Last. Xinchun Yang (Capital Medical University)H-Index: 18
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BACKGROUND Atrial fibrillation (AF) is a common arrhythmia in patients with hypertension. ELABELA, which has cardioprotective effects, is decreased in the plasma of patients with hypertension and might be associated with AF in the hypertensive population. This study aims to measure the ELABELA plasma levels in hypertension patients with and without AF and to analyse the related factors. METHODS A total of 162 hypertension patients with or without AF were recruited for our monocentric observation...
#1Zheng Liu (Capital Medical University)H-Index: 5
#2Yu Xia (Peking Union Medical College)H-Index: 1
Last. Xinchun Yang (Capital Medical University)H-Index: 18
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Background: Low voltage zones (LVZ) were usually targeted for ablation in atrial fibrillation (AF). However, its relationship with AF initiation, perpetuation, and termination remains to be studied. This study aimed to explore such relationships. Methods: A total of 126 consecutive AF patients were enrolled, including 71 patients for AF induction protocol and 55 patients for AF termination protocol. Inducible and sustainable AF were defined as induced AF lasting over 30 and 300 seconds, respecti...
#2Wen-Shu Zhao (Capital Medical University)H-Index: 6
Last. Xinchun Yang (Capital Medical University)H-Index: 18
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Resumo Fundamento: A fracao de ejecao (FE) tem sido utilizada em analises fenotipicas e na tomada de decisoes sobre o tratamento de insuficiencia cardiaca (IC). Assim, a FE tornou-se parte fundamental da pratica clinica diaria. Objetivo: Este estudo tem como objetivo investigar caracteristicas, preditores e desfechos associados a alteracoes da FE em pacientes com diferentes tipos de IC grave. Metodos: Foram incluidos neste estudo 626 pacientes com IC grave e classe III–IV da New York Heart Assoc...
#1Yuan Fu (Capital Medical University)H-Index: 3
#2Hao Sun (Capital Medical University)H-Index: 4
Last. Yuanfeng Gao (Capital Medical University)H-Index: 2
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Chronic kidney disease (CKD) significantly increases the rate of adverse cardiovascular events in patients with coronary artery disease. In this study, we aimed to establish a risk score (RS) model to predict in-hospital mortality risk in patients with end-stage renal disease (ESRD) and acute myocardial infarction (AMI). A total of 113 consecutive patients with ESRD and AMI were retrospectively enrolled between January 1, 2015 and December 31, 2019. All patients received regular hemodialysis and...
#1Yan-Jiang Wang (Capital Medical University)H-Index: 3
#2Ying Tian (Capital Medical University)H-Index: 6
Last. Xingpeng Liu (Capital Medical University)H-Index: 18
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Introduction Ablation index (AI)-guided radiofrequency ablation has been increasingly used for the treatment of drug-resistant paroxysmal atrial fibrillation (AF), but the optimal AI targets remain to be determined. We aimed to examine the efficacy and safety of catheter ablation guided by moderate AI values but more strict procedural endpoints in patients with paroxysmal AF. Methods We conducted a retrospective review of a consecutive series of patients who received their first AI-guided ablati...
1 CitationsSource