The enhancement of N-acetylcysteine on intestinal absorption and oral bioavailability of hydrophobic curcumin.

Published on Nov 1, 2020in European Journal of Pharmaceutical Sciences3.616
· DOI :10.1016/J.EJPS.2020.105506
Shanshan Zhang2
Estimated H-index: 2
(CPU: China Pharmaceutical University),
Sajid Asghar16
Estimated H-index: 16
(GCUF: Government College University, Faisalabad)
+ 5 AuthorsYanyu Xiao22
Estimated H-index: 22
(CPU: China Pharmaceutical University)
Abstract To solve the low oral bioavailability of curcumin (CUR) due to the limits imposed by gastrointestinal (GI) barrier, we constructed a nano delivery system to evaluate the effect of N-acetyl-L-cysteine (NAC) on intestinal absorption and oral bioavailability of CUR. CUR was first encapsulated in bovine serum albumin nanoparticles (CUR-BSA-NPs), and then was further modified by NAC (CUR-NBSA-NPs). In situ single-pass intestinal perfusion assay demonstrated that CUR-NBSA-NPs displayed excellent permeation and absorption rates in GI tract. Additionally, the distribution study in GI tract revealed that more NBSA-NPs were absorbed by intestinal segments compared to the BSA nanoparticles. Plasma concentration-time curves in rats showed that AUC0-t, Cmax and MRT0-t values of CUR after oral administration of CUR-NBSA-NPs were increased to 3.25-, 4.42-, and 1.43-fold compared with that of CUR suspension. In conclusion, NAC promotes oral absorption of CUR, thereby improving its oral bioavailability.
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