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Original paper

Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary

Volume: 117, Issue: 33, Pages: 20015 - 20026
Published: Aug 5, 2020
Abstract
We sequenced more than 52,500 single cells from embryonic day 11.5 (E11.5) postembryonic day 5 (P5) gonads and performed lineage tracing to analyze primordial follicles and wave 1 medullar follicles during mouse fetal and perinatal oogenesis. Germ cells clustered into six meiotic substages, as well as dying/nurse cells. Wnt-expressing bipotential precursors already present at E11.5 are followed at each developmental stage by two groups of...
Paper Details
Title
Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary
Published Date
Aug 5, 2020
Volume
117
Issue
33
Pages
20015 - 20026
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