Acylceramide is a key player in skin barrier function: insight into the molecular mechanisms of skin barrier formation and ichthyosis pathogenesis

For a quarter of the century, tremendous advances have been achieved in our understanding of the pathogenic mechanisms and relevant genetic defects underlying ichthyoses and ichthyosis syndromes. Research on the pathogenic mechanisms of ichthyoses has provided novel insights into the synthesis and metabolism of epidermal ceramides. Conversely, our advanced understanding of the dynamics of ceramides in the epidermis has contributed to the...