FEBS Journal
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#1Andrea E. Tóth (Lundbeck)H-Index: 12
#2Hans C. Helms (Lundbeck)
Last. Dora V. Lipka (AU: Aarhus University)
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Brain homeostasis depends on the existence of the blood-brain barrier (BBB). Despite decades of research, the factors and signalling pathways for modulating and maintaining BBB integrity are not fully elucidated. Here, we characterise the expression and function of the multifunctional receptor, sortilin, in the cells of the BBB, in vivo and in vitro. We show that sortilin acts as an important regulatory protein of the BBB's tightness. In rats lacking sortilin, the BBB was leaky, which correlated...
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#2Nektarios Tavernarakis (FORTH: Foundation for Research & Technology – Hellas)H-Index: 1
In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal and future directions in their field. Nektarios Tavernarakis is Chairman of the Board of Directors at the Foundation for Research and Technology-Hellas (FORTH), and Professor of Molecular Systems Biology at the University of Crete Medical School, Greece. In 2020, he was elected Vice President of the European Research Council (ERC). He has served ...
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#1Satomi Adegawa (Japan Society for the Promotion of Science)
#2Naomi Yamaguchi (TUAT: Tokyo University of Agriculture and Technology)
Last. Ryoichi Sato (TUAT: Tokyo University of Agriculture and Technology)H-Index: 28
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Little information is available regarding the region of Cry toxins involved in binding to their major receptors, the ATP-binding cassette (ABC) transporters. We analyzed which Cry1Aa amino acid residues contribute to binding to Bombyx mori ABC transporter C2 (BmABCC2). Several two oxidized double-cysteine substitution mutant toxins were made. In these, two amino acids at distant positions on toxin loop α8 and loop 2 or loop 2 and loop 3 were substituted with cysteine residues and crosslinked. Th...
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#1Junichi Ikenouchi (Kyushu University)H-Index: 20
#2Kana Aoki (Kyushu University)H-Index: 3
When the plasma membrane (PM) detaches from the underlying actin cortex, the PM expands according to intracellular pressure and a spherical membrane protrusion called a bleb is formed. This bleb retracts when the actin cortex is reassembled underneath the PM. Whereas this phenomenon seems simple at first glance, there are many interesting, unresolved cell biological questions in each process. For example, what is the membrane source to enlarge the surface area of the PM during rapid bleb expansi...
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#1Ching-In Lau (ICH: UCL Institute of Child Health)H-Index: 9
#2Diana C. Yánez (ICH: UCL Institute of Child Health)H-Index: 6
Last. Tessa Crompton (ICH: UCL Institute of Child Health)H-Index: 31
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Epithelial barrier tissues such as the skin and airway form an essential interface between the mammalian host and its external environment. These physical barriers are crucial to prevent damage and disease from environmental insults and allergens. Failure to maintain barrier function against such risks can lead to severe inflammatory disorders, including atopic dermatitis and asthma. Here, we discuss the role of the morphogen Sonic Hedgehog in postnatal skin and lung and the impact of Shh signal...
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#1Tianshu Gui (UU: Utrecht University)H-Index: 1
#2Boudewijn M.T. Burgering (UU: Utrecht University)H-Index: 67
Forkhead box O (FOXO) transcription factors (TFs) are a subclass of the larger family of forkhead TFs. Mammalians express four members FOXO1, FOXO3, FOXO4, and FOXO6. The interest in FOXO function stems mostly from their observed role in determining lifespan, where in model organisms, increased FOXO activity results in extended lifespan. FOXOs act as downstream of several signaling pathway and are extensively regulated through post-translational modifications. The transcriptional program activat...
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#1Manuela Sollazzo (UNIBO: University of Bologna)H-Index: 6
#2Monica De Luise (UNIBO: University of Bologna)H-Index: 5
Last. Giuseppe Gasparre (UNIBO: University of Bologna)H-Index: 31
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Mitochondria act as key organelles in cellular bioenergetics and biosynthetic processes producing signals that regulate different molecular networks for proliferation and cell death. This ability is also preserved in pathologic contexts such as tumorigenesis, during which bioenergetic changes and metabolic reprogramming confer flexibility favoring cancer cell survival in a hostile microenvironment. Although different studies epitomize mitochondrial dysfunction as a protumorigenic hit, genetic ab...
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#1Xinmin Qian (THU: Tsinghua University)
#2Xia Meng (THU: Tsinghua University)
Last. Wenwen Zeng (THU: Tsinghua University)H-Index: 13
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The white adipose tissues (WAT) are located in distinct depots throughout the body. They serve as an energy reserve, providing fatty acids for other tissues via lipolysis when needed, and function as an endocrine organ to regulate systemic metabolism. Their activities are coordinated through intercellular communications among adipocytes and other cell types such as residential and infiltrating immune cells, which are collectively under neuronal control. The adipocytes and immune subtypes includi...
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#1Ming-Chih Lai (CGU: Chang Gung University)H-Index: 14
#2Yi-Pin Chen (CGU: Chang Gung University)
Last. Woan-Yuh Tarn (AS: Academia Sinica)H-Index: 35
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Here, we describe a novel interaction between the RNA helicase DDX3 and the deubiquitinase ubiquitin-specific peptidase 9 X-linked (USP9X) in human cells. Domain mapping studies reveal that the C-terminal region of DDX3 interacted with the N terminus of USP9X. USP9X was predominantly localized in the cytoplasm where the interaction between DDX3 and USP9X occurred. USP9X was not visibly enriched in cytoplasmic stress granules (SGs) under oxidative stress conditions, whereas overexpression of GFP-...
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#1Silke von Horsten (University of Marburg)H-Index: 4
#2Marie-Luise Lippert (University of Marburg)H-Index: 1
Last. Johann Heider (University of Marburg)H-Index: 53
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Anaerobic toluene degradation proceeds by fumarate addition to produce (R)-benzylsuccinate as first intermediate, which is further degraded via β-oxidation by five enzymes encoded in the conserved bbs operon. This study characterizes two enzymes of this pathway, (E)-benzylidenesuccinyl-CoA hydratase (BbsH), and (S,R)-2-(α-hydroxybenzyl)succinyl-CoA dehydrogenase (BbsCD) from Thauera aromatica. BbsH, a member of the enoyl-CoA hydratase family, converts (E)-benzylidenesuccinyl-CoA to 2-(α-hydroxyb...
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