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#1Iván Parra-Izquierdo (CSIC: Spanish National Research Council)H-Index: 3
#2Tania Sánchez-Bayuela (CSIC: Spanish National Research Council)
Last. Carmen García-Rodríguez (CSIC: Spanish National Research Council)H-Index: 20
view all 8 authors...
Calcific aortic valve disease (CAVD) is the most prevalent valvulopathy worldwide. Growing evidence supports a role for viral and cell-derived double-stranded (ds)-RNA in cardiovascular pathophysiology. Poly(I:C), a dsRNA surrogate, has been shown to induce inflammation, type I interferon (IFN) responses, and osteogenesis through Toll-like receptor 3 in aortic valve interstitial cells (VIC). Here, we aimed to determine whether IFN signaling via Janus kinase (JAK)/Signal transducers and activator...
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#1Marco Rasile (Humanitas University)H-Index: 6
#2Eliana LauranzanoH-Index: 3
Last. Michela Matteoli (Humanitas University)H-Index: 59
view all 4 authors...
Intragravidic and perinatal infections, acting through either direct viral-effect or immune-mediated responses, are recognized causes of liability for neurodevelopmental disorders in the progeny. The large amounts of epidemiological data and the wealth of information deriving from animal models of gestational infections, have contributed to delineate, in the last years, possible underpinning mechanisms for this phenomenon, including defects in neuronal migration, impaired spine and synaptic deve...
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#1Dennis Pedri (Katholieke Universiteit Leuven)H-Index: 1
#2Panagiotis Karras (Katholieke Universiteit Leuven)H-Index: 8
Last. Florian Rambow (Katholieke Universiteit Leuven)H-Index: 21
view all 5 authors...
Epithelial-to-mesenchymal transition (EMT), a process through which epithelial tumor cells acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination and therapy resistance in cancer. Accumulating evidence indicates that non-epithelial tumors, including melanoma, can also gain mesenchymal-like properties that increase their metastatic propensity and decrease their sensitivity to therapy. In this review, we discuss recent findings, illustrating the striking similariti...
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#1Alexander Botvinnik (HUJI: Hebrew University of Jerusalem)
#2Pushkar Shivam (HUJI: Hebrew University of Jerusalem)
Last. Moshe Kotler (HUJI: Hebrew University of Jerusalem)H-Index: 29
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Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (hA3G), a member of the APOBEC family, was described as an anti-HIV-1 restriction factor, deaminating reverse transcripts of the HIV-1 genome. Several types of cancer cells that express high levels of A3G, such as diffuse large B-cell lymphoma cells and glioblastomas, show enhanced cell survival after ionizing radiation (IR) and chemotherapy treatments. Previously, we showed that hA3G promotes (DNA) double-strand breaks re...
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#1Stephanie Schumacher (MPG: Max Planck Society)H-Index: 2
#2Roberto Vazquez Nunez (NIH: National Institutes of Health)
Last. Naoko Mizuno (NIH: National Institutes of Health)H-Index: 19
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Focal adhesions (FA) are large macromolecular assemblies relevant for various cellular and pathological events such as migration, polarization and metastatic cancer formation. At FA sites at the migrating periphery of a cell, hundreds of players gather and form a network to respond to extra cellular stimuli transmitted by the integrin receptor, the most upstream component within a cell, initiating the FA signaling pathway. Numerous cellular experiments have been performed to understand the FA ar...
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#1Daniela Cerezo-Wallis (Centro Nacional de Investigaciones Cardiovasculares)
#2Iván Ballesteros (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 18
Neutrophils dominate the immunological landscape of multiple types of solid tumours in mice and humans and exert different pro or anti-tumoral activity. This functional heterogeneity has prompted a search for different subsets and classifications of tumour infiltrating neutrophils with the idea of better delineating their specific roles in cancer. In this review we describe current studies that highlight specific mechanisms by which neutrophils exert - pro- or antitumoral function and focus on h...
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#1Anna-Lena Köpnick (CAU: University of Kiel)
#2Katharina Geistlinger (CAU: University of Kiel)
Last. Eric Beitz (CAU: University of Kiel)H-Index: 28
view all 3 authors...
Monocarboxylate transporter isoforms 1-4, MCT, of the solute carrier SLC16A family facilitate proton-coupled transport of l-lactate. Growth of tumors that exhibit the Warburg effect, i.e. high rates of anaerobic glycolysis despite availability of oxygen, rely on swift l-lactate export, whereas oxygenic cancer cells import circulating l-lactate as a fuel. Currently, MCTs are viewed as promising anticancer targets. Small-molecule inhibitors have been found, and, recently, high-resolution protein s...
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#1Takuya Tada (NYU: New York University)H-Index: 7
#2Yanzhao Zhang (NIH: National Institutes of Health)H-Index: 5
Last. Kenzo Tokunaga (NIH: National Institutes of Health)H-Index: 25
view all 4 authors...
Membrane-associated RING-CH (MARCH) family member proteins are RING-finger E3 ubiquitin ligases that are known to downregulate cellular transmembrane proteins. MARCH8 is a novel antiviral factor that inhibits HIV-1 envelope glycoprotein and vesicular stomatitis virus G by downregulating these envelope glycoproteins from the cell surface, resulting in their reduced incorporation into virions. More recently, we have found that MARCH8 reduces viral infectivity via two different mechanisms. Addition...
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#2Giuliana GiamundoH-Index: 2
Last. Ivan Conte (University of Naples Federico II)H-Index: 20
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The retinal pigment epithelium (RPE) is a highly specialised monolayer of polarized, pigmented epithelial cells that resides between the vessels of the choriocapillaris and the neural retina. The RPE is essential for the maintenance and survival of overlying light-sensitive photoreceptors, as it participates in the formation of the outer blood retinal barrier, phagocytosis, degradation of photoreceptor outer segment (POS) tips, maintenance of the retinoid cycle, and protection against light and ...
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#1Diana Moita (IMM: Instituto de Medicina Molecular)
#2Helena Nunes-Cabaço (IMM: Instituto de Medicina Molecular)H-Index: 7
Last. Miguel Prudêncio (IMM: Instituto de Medicina Molecular)H-Index: 31
view all 4 authors...
In the last few decades, considerable efforts have been made towards the development of efficient vaccines against malaria. Whole-sporozoite (Wsp) vaccines, which induce efficient immune responses against the pre-erythrocytic (PE) stages (sporozoites and liver forms) of Plasmodium parasites, the causative agents of malaria, are among the most promising immunization strategies tested until present. Several Wsp PE vaccination approaches are currently under evaluation in the clinic, including radia...
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