Head and Neck Cancer Metastasis and the Effect of the Local Soluble Factors, from the Microenvironment, on Signalling Pathways: Is It All about the Akt?

Hanan Ahmed; Arpa Ghoshal; Sarah J. Jones; Ian Ellis; Mohammad Islam

doi:https://doi.org/10.3390/cancers12082093

doi.org/10.3390/cancers12082093

Head and Neck Cancer Metastasis and the Effect of the Local Soluble Factors, from the Microenvironment, on Signalling Pathways: Is It All about the Akt?

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..., Mohammad Islam

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Cancers5.20

Volume: 12, Issue: 8, Pages: 2093 - 2093

Published: Jul 28, 2020

Abstract

The signalling pathways involved in metastasis of oral adenoid cancer cells (TYS) in response to cancer-associated fibroblasts (COM D24) and normal oral mucosal fibroblasts (MM1) was examined. Metastatic cell behaviour was observed by cell-scatter, 3-D-collagen gel migration, and 3-D-spheroid invasion assays. Akt (v-Akt murine thymoma viral oncogene), MAPK(Mitogen activated protein kinase), EGFR (Epidermal growth factor receptor), TGFβRI...