Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis

Background: As a degenerative joint disease, osteoarthritis (OA) has no satisfactory therapy to date. In traditional Chinese medicine (TCM), Aconitum carmichaeli derived Hei-shun-pian (Hsp) has been developed for joint pain treatment. However, it causes adverse events in patients. Long-time decoction has been traditionally applied to reduce the aconite toxicity of aconite herbs, but its detoxifying effect is uncertain. Methods: Hsp was extracted...