Review paper
Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
Abstract
Carbonic anhydrases (CAs, EC 4.2.1.1) are widely distributed metalloenzymes in both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon dioxide to bicarbonate and H+ ions and play a crucial role in regulating many physiological processes. CAs are well-studied drug target for various disorders such as glaucoma, epilepsy, sleep apnea, and high altitude sickness. In the past decades, a large category of diverse...
Paper Details
Title
Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
Published Date
Jul 21, 2020
Journal
Volume
40
Issue
6
Pages
2485 - 2565
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