Structure of the human sodium leak channel NALCN

Persistently depolarizing sodium (Na+) leak currents enhance electrical excitability1,2. The ion channel responsible for the major background Na+ conductance in neurons is the Na+ leak channel, non-selective (NALCN)3,4. NALCN-mediated currents regulate neuronal excitability linked to respiration, locomotion and circadian rhythm4–10. NALCN activity is under tight regulation11–14 and mutations in NALCN cause severe neurological disorders and early...