Sustained drug release and bactericidal activity of a novel, highly biocompatible and biodegradable polymer nanocomposite loaded with norfloxacin for potential use in antibacterial therapy

In this study, novel poly(3-hydroxybutyrate) (PHB) based Calcium–Iron Layered Double Hydroxide (Ca–Fe LDH) nanocomposites were investigated for sustained drug delivery application using the antibiotic norflaxacin (NFX) as a model drug. Compared with other LDH and montmorillonite nanoclays, Ca–Fe LDH showed a high drug loading capacity. In vitro drug release experiments with PHB/NFX, PHB/NFX LDH, and PHB/PEG/NFX LDH were performed using two...