Associations between age and brain microstructure in older community-dwelling men and women: the Rancho Bernardo Study.

Published on Nov 1, 2020in Neurobiology of Aging4.347
· DOI :10.1016/J.NEUROBIOLAGING.2020.07.007
Emilie T. Reas13
Estimated H-index: 13
(UCSD: University of California, San Diego),
Donald J. Hagler88
Estimated H-index: 88
(UCSD: University of California, San Diego)
+ 3 AuthorsLinda K. McEvoy66
Estimated H-index: 66
(UCSD: University of California, San Diego)
Sources
Abstract
Abstract Cytoarchitectural brain changes within gray matter and fiber tracts during normal aging remain poorly characterized, and it is unclear whether rates and patterns of brain aging differ by sex. This study used restriction spectrum imaging (RSI) to examine associations between age and brain microstructure in 147 community-dwelling participants (aged 56-99). Widespread associations with older age in multiple diffusion compartments, including increased free water, decreased restricted and hindered diffusion, and reduced neurite complexity, were observed diffusely in cortical gray matter, multiple white matter tracts, and the hippocampus. Age differences in cortical microstructure were largely independent of cortical thinning. Age-microstructure associations were mostly global, though regional foci of stronger effects emerged in fornix, anterior thalamic radiation and commissural fibers, as well as in medial temporal, orbitofrontal, and occipital cortex. Age differences in gray and white matter microstructure were stronger and more widespread for women than men, even after adjustment for education, hypertension and BMI. RSI may be a convenient, non-invasive tool for monitoring changes in gray and white matter diffusion properties thought to reflect reduced cellular fractions, neurite density, or neurite complexity, that occur with typical aging, and for detecting sex differences in patterns of brain aging.
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