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doi.org/10.1158/0008-5472.can-19-4044

FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling

..., Daniela Matei
54
Cancer Research11.20
Volume: 80, Issue: 16, Pages: 3200 - 3214
Published: Jun 30, 2020
Abstract

N6-Methyladenosine (m6A) is the most abundant modification of mammalian mRNAs. RNA methylation fine tunes RNA stability and translation, altering cell fate. The fat mass- and obesity-associated protein (FTO) is an m6A demethylase with oncogenic properties in leukemia. Here, we show that FTO expression is suppressed in ovarian tumors and cancer stem cells (CSC). FTO inhibited the...
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Paper Details
Title
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling
DOI
doi.org/10.1158/0008-5472.can-19-4044
Published Date
Jun 30, 2020
Journal
Cancer Research
Volume
80
Issue
16
Pages
3200 - 3214
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