Prognostic factors of biochemical remission after transsphenoidal surgery for acromegaly: a structured review

Biochemical control is the main determinant of survival, clinical manifestations and comorbidities in acromegaly. Transsphenoidal selective adenomectomy (TSA) is the initial treatment of choice with reported biochemical remission rates varying between 32 and 85%. Understanding the limiting factors is essential for identification of patients who require medical treatment. We reviewed the English literature published in Medline/Pubmed until Dec...