Original paper
Single-molecule regulatory architectures captured by chromatin fiber sequencing
Abstract
Primary architecture of chromatin fibers The organization of chromosomal DNA, including the positioning of nucleosomes and nucleosome-free regions harboring regulatory proteins along single chromatin fibers, is fundamental to genome function. However, most sequencing methods cannot elucidate this organization at the nucleotide level. Stergachis et al. present an approach, Fiber-seq, that maps chromatin fibers onto the underlying DNA template...
Paper Details
Title
Single-molecule regulatory architectures captured by chromatin fiber sequencing
Published Date
Jun 25, 2020
Journal
Volume
368
Issue
6498
Pages
1449 - 1454