Alveolar ridge

Scaffold

Cell biology

Biology

Biomedical engineering

Metallurgy

Materials science

Surgery

Regeneration (biology)

Soft tissue

Nano-

Dentistry

Bone healing

Geology

Paleontology

Dental alveolus

Anatomy

Politics

Political science

Implant

Ridge

Promotion (chess)

Biocompatibility

Composite material

Medicine

Chemistry

Wound healing

Materials Science and Engineering C

In stomatology, the promotion of alveolar bone regeneration while preventing the reduction of ridge absorption remains a challenge. In this work, we designed and prepared bio-mimetic polysaccharide hydrogels that are multi-functional in terms of being injectable, promote self-healing, degradable, porous structure, et al. After introducing nano-hydroxyapatite particles, the composite scaffold of hydrogel/hydroxyapatite (GH) stent was obtained. When GH material was injected into the mandibular incisors of rats following tooth extraction, the new bone area was enhanced more than 50%, while the alveolar ridge was promoted in excess of 60% after 4 weeks. What's more, the wound soft tissue was healed within 1 week. Overall, our results indicate that this optimized GH stent has the potential to both maintain dimensional alveolar ridge, as well as to promote soft tissue healing. Moreover, using the hydroxyapatite-containing hydrogel platform has the potential to promote bone and soft tissue regeneration.

Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion