Review paper
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance
Abstract
It is well established that multifactorial drug resistance hinders successful cancer treatment. Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial-mesenchymal transition (EMT) and multidrug resistance (MDR). TME-induced factors secreted by cancer cells and cancer-associated fibroblasts (CAFs) create an inflammatory microenvironment by recruiting immune cells. CD11b+/Gr-1+ myeloid-derived suppressor cells...
Paper Details
Title
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance
Published Date
Dec 1, 2020
Journal
Volume
53
Pages
100715 - 100715
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