Leucine regulates autophagy via acetylation of the mTORC1 component raptor
Abstract
Macroautophagy (“autophagy”) is the main lysosomal catabolic process that becomes activated under nutrient-depleted conditions, like amino acid (AA) starvation. The mechanistic target of rapamycin complex 1 (mTORC1) is a well-conserved negative regulator of autophagy. While leucine (Leu) is a critical mTORC1 regulator under AA-starved conditions, how Leu regulates autophagy is poorly understood. Here, we describe that in most cell types,...
Paper Details
Title
Leucine regulates autophagy via acetylation of the mTORC1 component raptor
Published Date
Jun 19, 2020
Journal
Volume
11
Issue
1
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