Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
Abstract
Chemokines are important protein-signaling molecules that regulate various immune responses by activating chemokine receptors which belong to the G protein-coupled receptor (GPCR) superfamily. Despite the substantial progression of our structural understanding of GPCR activation by small molecule and peptide agonists, the molecular mechanism of GPCR activation by protein agonists remains unclear. Here, we present a 3.3-Å cryo-electron microscopy...
Paper Details
Title
Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
Published Date
Jun 15, 2020
Journal
Volume
11
Issue
1
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