Supervised Exercise Intervention and Overall Activity in CKD.

Published on Jun 15, 2020in Kidney International Reports3.374
· DOI :10.1016/J.EKIR.2020.06.006
Mindy Pike4
Estimated H-index: 4
(VUMC: Vanderbilt University Medical Center),
Aseel Alsouqi3
Estimated H-index: 3
(VUMC: Vanderbilt University Medical Center)
+ 10 AuthorsCassianne Robinson-Cohen34
Estimated H-index: 34
(VUMC: Vanderbilt University Medical Center)
Abstract Introduction Patients are often instructed to engage in multiple weekly sessions of exercise to increase physical activity. We aimed to determine whether assignment to a supervised exercise regimen increases overall weekly activity in individuals with chronic kidney disease (CKD). Methods We performed a secondary analysis of a pilot randomized 2x2 factorial design trial examining the effects of diet and exercise (10-15% reduction in caloric intake, three supervised exercise sessions/week, combined diet restriction/exercise, and control). Activity was measured as counts detected by accelerometer. Counts data were collected on all days for which an accelerometer was worn at baseline, month 2, and month 4 follow-up. The primary outcome was a relative change from baseline in log-transformed counts/minute. Generalized estimating equations were used to compare the primary outcome in individuals in the exercise group and the non-exercise group. Results We examined 111 individuals randomized to aerobic exercise or usual activity (n=48 in exercise group and n=44 controls). The mean age was 57 years, 42% were female, and 28% were black. Median overall adherence over all time was 73%. Median (25th, 75th percentile) counts/minute over non-supervised exercise days at months 2 and 4 were 237.5 (6.5, 444.4) for controls and 250.9 (7.7, 529.8) for the exercise group (p=0.74). No difference was observed in the change in counts/min between the exercise and control groups over three time points (Beta (fold change): 0.96, 95% CI: 0.91, 1.02). Conclusions Engaging in supervised exercise program does not increase overall weekly physical activity in individuals with Stage 3-4 CKD.
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Author(s): Arnett, Donna K; Blumenthal, Roger S; Albert, Michelle A; Buroker, Andrew B; Goldberger, Zachary D; Hahn, Ellen J; Himmelfarb, Cheryl D; Khera, Amit; Lloyd-Jones, Donald; McEvoy, J William; Michos, Erin D; Miedema, Michael D; Munoz, Daniel; Smith, Sidney C; Virani, Salim S; Williams, Kim A; Yeboah, Joseph; Ziaeian, Boback
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