Original paper
Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids
Abstract
Luminal pH and the distinctive distribution of phosphatidylinositol phosphate (PIP) lipids are central identifying features of organelles in all eukaryotic cells that are also critical for organelle function. V-ATPases are conserved proton pumps that populate and acidify multiple organelles of the secretory and the endocytic pathway. Complete loss of V-ATPase activity causes embryonic lethality in higher animals and conditional lethality in...
Paper Details
Title
Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids
Published Date
Jun 23, 2020
Volume
8