Early administration of ritonavir-boosted lopinavir could prevent severe COVID-19

•No specific treatment against SARS-CoV-2 is available after 6 months of COVID-19 worldwide outbreak.•Antivirals could decrease the viral load and reduce direct and indirect damages of SARSCoV-2 infection.•Ritonavir-bosted lopinavir is effective against SARS-CoV-2 in vitro.•Sequential virological and pharmacological monitoring helped to understand the efficacy of ritonavir-boosted lopinavir in a SARS-CoV-2 infected patient.•Ritonavir-boosted...