Pathogenesis of impaired diabetic wound healing

Published on Mar 20, 2014
· DOI :10.3760/CMA.J.ISSN.1673-4157.2014.02.017
Yuejie Chu (Tianjin Medical University), Penghua Wang (Tianjin Medical University)
In diabetic patients,the impaired wound healing is a common clinical problem and needs to be solved urgently.Its exact pathogenesis is unclear.It is probably the result of joint action of many complex factors.Recent studies show that it may be associated with the accumulation of advanced glycation end products,the increased oxidative stress and cell apoptosis caused by hyperglycemia.Simultaneously,growth factors deficiency,abnormal expression of inflammatory cytokines,angiogenesis-related cells dysfunction (such as endothelial progenitor cell,and extracellular matrix destruction)would hinder the wound healing in diabetic patients.Furthermore,the epigenetic changes caused by hyperglycemia might also cause a prolonged wound healing in diabetic patients.Further studies about the pathogenesis of the impaired diabetic wound healing will provide new therapeutic targets for the improvement of diabetic wound healing. Key words: Diabetic mellitus;  Wound healing;  Growth factor;  Inflammatory cytokine ;  Angiogenesis; Epigenetic
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