Pathogenesis of impaired diabetic wound healing

In diabetic patients,the impaired wound healing is a common clinical problem and needs to be solved urgently.Its exact pathogenesis is unclear.It is probably the result of joint action of many complex factors.Recent studies show that it may be associated with the accumulation of advanced glycation end products,the increased oxidative stress and cell apoptosis caused by hyperglycemia.Simultaneously,growth factors deficiency,abnormal expression of...