Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer

Here we investigated the roles of Rab27a, a player in exosome release, and TRAF3IP2, an inflammatory mediator, in development and metastasis of breast cancer (BC) in vivo . Knockdown (KD) of Rab27a (MDA KDRab27a ) or TRAF3IP2 (MDA KDTRAF3IP2 ) in triple negative MDA-MB231 cells reduced tumor growth by 70–97% compared to wild-type tumors (MDA w ). While metastasis was detected in MDA w -injected animals, none was detected in MDA KDRab27a - or MDA...