Adipose-Derived Mesenchymal Stromal Cells in Regenerative Medicine: State of Play, Current Clinical Trials, and Future Prospects.

Published on Jan 1, 2021in Advances in wound care2.813
· DOI :10.1089/WOUND.2020.1175
Jérôme Laloze6
Estimated H-index: 6
(University of Limoges),
Loïc Fievet1
Estimated H-index: 1
(University of Toulouse),
Alexis Desmoulière49
Estimated H-index: 49
(University of Limoges)
Sources
Abstract
Significance: Wound healing is a complex process involving pain and inflammation, where innervation plays a central role. Managing wound healing and pain remains an important issue especiall...
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: Recent years have brought an enhanced understanding of keratinocyte contribution to cutaneous nociception. While intra-epidermal nerve endings were classically considered as the exclusive transducers of cutaneous noxious stimuli, it has now been demonstrated that epidermal keratinocytes can initiate nociceptive responses, like Merkel cells do for the innocuous mechanotransduction. In the light of recent in vivo findings, this article outlines this paradigm shift that points to a not yet consid...
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