Deciphering the role of selenium-enriched rice protein hydrolysates in the regulation of Pb2+-induced cytotoxicity: an in vitro Caco-2 cell model study

Published on Jan 1, 2021in International Journal of Food Science and Technology2.773
· DOI :10.1111/IJFS.14657
Yiqing Zhu3
Estimated H-index: 3
(NU: Nanjing University),
Jian Ding2
Estimated H-index: 2
(NU: Nanjing University)
+ 5 AuthorsQiuhui Hu44
Estimated H-index: 44
(Nanjing University of Finance and Economics)
📖 Papers frequently viewed together
9 Authors (Yong Fang, ..., Qiu Weifen)
19 Citations
19 Citations
1 Author (Zhong Ping)
#1Himani Agrawal (AcSIR: Academy of Scientific and Innovative Research)H-Index: 4
#2Robin Joshi (AcSIR: Academy of Scientific and Innovative Research)H-Index: 16
Last. Mahesh Gupta (AcSIR: Academy of Scientific and Innovative Research)H-Index: 9
view all 3 authors...
Abstract Antioxidant peptides were successfully identified from a finger millet protein hydrolysate. The trypsin hydrolysate showed a higher degree of hydrolysis (17.47 ± 0.63%) than the pepsin hydrolysate, was further fractionated by ultrafiltration membrane [ 10 kDa (UF1)]. UF3 with higher antioxidant activity (48.41 ± 0.21%) was further fractionated into five fractions (GFA, GFB, GFC, GFD and GFE) using gel filtration. Fraction GFB possessed the highest antioxidant activity (61.79 ± 0.08%) an...
47 CitationsSource
#1Kai Yin (NEAU: Northeast Agricultural University)H-Index: 4
#2Zijiang Yang (NEAU: Northeast Agricultural University)H-Index: 1
Last. Hongjin Lin (NEAU: Northeast Agricultural University)H-Index: 2
view all 5 authors...
Abstract Neutrophils represent an important part of the body's innate immunity and can resist the invasion of pathogenic microorganisms by releasing neutrophil extracellular traps (NETs). In this study, we investigated the toxic effects of lead (Pb) on the release of NETs, the antagonism of selenium (Se) on Pb toxicity and the potential molecular mechanisms. Our model was an in vitro exposure model for the addition of Se, Pb or both in the culture medium and was based on the separation of neutro...
11 CitationsSource
#1Tongsen Zhang (JLU: Jilin University)H-Index: 1
#2Si Chen (JLU: Jilin University)H-Index: 2
Last. Jiandong Tai (JLU: Jilin University)H-Index: 2
view all 8 authors...
Lead (Pb) exposure is a global environmental problem and its exposure can lead to serious renal damage by disturbing the pro-oxidant/antioxidant balance and facilitating inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenols in the diet and has been reported to have many biological properties such as antioxidant and anti-inflammatory. In this study, we aimed to investigate the protective efficacy and mechanism of CGA against Pb-induced nephrotoxicity in mice. The results sh...
15 CitationsSource
#1Marek Kieliszek (Warsaw University of Life Sciences)H-Index: 20
Selenium is a micronutrient that is essential for the proper functioning of all organisms. Studies on the functions of selenium are rapidly developing. This element is a cofactor of many enzymes, for example, glutathione peroxidase or thioredoxin reductase. Insufficient supplementation of this element results in the increased risk of developing many chronic degenerative diseases. Selenium is important for the protection against oxidative stress, demonstrating the highest activity as a free radic...
77 CitationsSource
#1Yong Fang (Nanjing University of Finance and Economics)H-Index: 20
#2Xin Pan (Nanjing University of Finance and Economics)H-Index: 4
Last. Qiu Weifen (Nanjing University of Finance and Economics)H-Index: 4
view all 9 authors...
Abstract The RAW264.7 cell model was employed to screen immunomodulatory selenium-containing peptides from selenium-enriched rice protein hydrolysates (SPHs). Moreover, the selenium-containing peptides of high-activity protein hydrolysates were purified by Sephadex G-25, and identified by reversed phase ultra performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry. The results showed that 25 peptide sequences containing selenomethionine (SeMet) informati...
19 CitationsSource
#1Chunli LiuH-Index: 3
#2Liyao Xu (Hebei University)H-Index: 3
Last. Tiesheng ShiH-Index: 13
view all 6 authors...
Abstract Se-methyl L-selenocysteine (MeSeCys) is one of the major organic selenium compounds acquired from the diet by human beings. It has been shown to have anticancer activity and cancer prevention functions. However, its antioxidant activity, largely related to its biological function, has not been well characterized so far. We here report a stopped-flow kinetic study of the reduction of the Pt(IV) anticancer model compounds trans-[PtX2(CN)4]2− (X = Cl; Br) by MeSeCys in a wide pH range. Ove...
6 CitationsSource
#1Hossein Khoshsang (IUST: Iran University of Science and Technology)H-Index: 3
#2Ali Ghaffarinejad (IUST: Iran University of Science and Technology)H-Index: 20
Abstract In this work for the first time Saffron flower waste as a low cost and green adsorbent for removal of lead toxic ions from aqueous solution by shaking and ultrasonic waves is reported. Properties of this natural absorbent are characterized by scanning electron microscopy, Fourier transform infrared spectroscopy (FTIR) and energy dispersive X-ray diffraction (EDX). The specific surface area of the saffron flower waste is measured via Brunauer–Emmett–Teller. The effect of some important p...
12 CitationsSource
#1Monica Shirley Mani (Manipal University)H-Index: 3
#2Vidya Kunnathully (Manipal University)H-Index: 1
Last. Herman Sunil Dsouza (Manipal University)H-Index: 5
view all 6 authors...
Abstract Lead is an environmental hazard with great public health concern and has been known to inhibit delta-aminolevulinate dehydratase (ALAD) activity involved in the heme biosynthetic pathway. The study aimed to investigate the influence of ALAD polymorphism (G177C) on retention of Pb-B levels and ALAD activity on occupationally exposed lead workers. In the present study, we enrolled 561 lead exposed and 317 non-occupationally exposed subjects and performed a comprehensive analysis of Pb-B l...
12 CitationsSource
#1Qiaozhi Zhang (NEAU: Northeast Agricultural University)H-Index: 12
#1Qiaozhi Zhang (NEAU: Northeast Agricultural University)H-Index: 6
Last. Lianzhou Jiang (NEAU: Northeast Agricultural University)H-Index: 24
view all 7 authors...
Abstract Peptides from Alcalase-hydrolyzed soybean protein hydrolysate (SPH) may hold the potential as natural antioxidants. In addition, the effect of human gastrointestinal (GI) tract on peptide bioavailability needs to be explored. In this study, the impact of simulated GI digestion and transepithelial transport on various antioxidant properties of SPH were investigated. SPH displayed DPPH radical scavenging (IC50 = 4.22 mg/mL), ABTS + radical scavenging (IC50 = 2.93 mg/mL), reducing power an...
37 CitationsSource
#1Patrick Saunders (Staffordshire University)H-Index: 4
#2David McCoy (QMUL: Queen Mary University of London)H-Index: 29
Last. A. MunroeH-Index: 1
view all 5 authors...
The public health impact of hydraulic fracturing remains a high profile and controversial issue. While there has been a recent surge of published papers, it remains an under-researched area despite being possibly the most substantive change in energy production since the advent of the fossil fuel economy. We review the evidence of effects in five public health domains with a particular focus on the UK: exposure, health, socio-economic, climate change and seismicity. While the latter would seem n...
38 CitationsSource
Cited By3
#1Rong Huang (NCU: Nanchang University)H-Index: 2
#2Jianhua Xie (NCU: Nanchang University)H-Index: 35
Last. Mingyue Shen (NCU: Nanchang University)H-Index: 29
view all 4 authors...
Abstract Our previous study has demonstrated that sulfated yam polysaccharide (SCYP) had a stronger immunomodulatory activity than yam polysaccharide (CYP). In order to investigate how the sulfated modification influence the immunological activity of CYP, this research was mainly focused on the study of gut microbiotal. The results showed that SCYP treatment could increase the digestive enzyme activities of colon contents and restore the production of short-chain fatty acids (SCFAs) in mice that...
#1Minhao Xie (Nanjing University of Finance and Economics)H-Index: 6
#2Xinyang Sun (UM: University of Manitoba)
Last. Yong Fang (Nanjing University of Finance and Economics)H-Index: 20
view all 5 authors...
Selenium (Se) is a trace mineral micronutrient essential for human health. The diet is the main source of Se intake. Se-deficiency is associated with many diseases, and up to 1 billion people suffer from Se-deficiency worldwide. Cereals are considered a good choice for Se intake due to their daily consumption as staple foods. Much attention has been paid to the contents of Se in cereals and other foods. Se-enriched cereals are produced by biofortification. Notably, the gap between the nutritiona...
1 CitationsSource
#1Jian Wu (Nanjing University of Finance and Economics)H-Index: 3
#2Jian Ding (Nanjing University of Finance and Economics)H-Index: 2
Last. Qiuhui Hu (Nanjing University of Finance and Economics)H-Index: 44
view all 10 authors...
Abstract Previous studies have revealed that Selenium-enriched rice protein hydrolysates (SPHs) could alleviate Pb2+-induced apoptosis in RAW264.7 macrophages. The purpose of the current study was to detect the effect of different selenium (Se) species on immunotoxicity of the Pb2+-induced RAW264.7 macrophages and explore the potential immunomodulatory mechanism. Herein, SPHs, an isolated SPHs fraction (SPHs-2), selenomethionine (SeMet), selenite (SeIV) were used to investigate their inhibitory ...
1 CitationsSource