Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring
Abstract
In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep targeted sequencing paradigm. We reasoned that breadth may supplant depth of sequencing to overcome the barrier of cfDNA abundance....
Paper Details
Title
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring
Published Date
Jun 1, 2020
Journal
Volume
26
Issue
7
Pages
1114 - 1124
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