Nitroxyl: A Novel Strategy to Circumvent Diabetes Associated Impairments in Nitric Oxide Signaling

Diabetes is associated with an increased mortality risk due to cardiovascular complications. Hyperglycemia-induced oxidative stress underlies these complications, leading to an impairment in endogenous nitric oxide (NO.) generation, together with reductions in NO. bioavailability and NO. responsiveness in the vasculature, platelets and myocardium. The latter impairment of responsiveness to NO., termed NO. resistance, compromises the ability of...