Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.

Published on Mar 1, 2021in Addiction Biology4.121
· DOI :10.1111/ADB.12914
Qingyu Zhao8
Estimated H-index: 8
(Stanford University),
Edith V. Sullivan111
Estimated H-index: 111
(Stanford University)
+ 19 AuthorsKilian M. Pohl27
Estimated H-index: 27
(Stanford University)
: Exogenous causes, such as alcohol use, and endogenous factors, such as temperament and sex, can modulate developmental trajectories of adolescent neurofunctional maturation. We examined how these factors affect sexual dimorphism in brain functional networks in youth drinking below diagnostic threshold for alcohol use disorder (AUD). Based on the 3-year, annually acquired, longitudinal resting-state functional magnetic resonance imaging (MRI) data of 526 adolescents (12-21 years at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) cohort, developmental trajectories of 23 intrinsic functional networks (IFNs) were analyzed for (1) sexual dimorphism in 259 participants who were no-to-low drinkers throughout this period; (2) sex-alcohol interactions in two age- and sex-matched NCANDA subgroups (N = 76 each), half no-to-low, and half moderate-to-heavy drinkers; and (3) moderating effects of gender-specific alcohol dose effects and a multifactorial impulsivity measure on IFN connectivity in all NCANDA participants. Results showed that sex differences in no-to-low drinkers diminished with age in the inferior-occipital network, yet girls had weaker within-network connectivity than boys in six other networks. Effects of adolescent alcohol use were more pronounced in girls than boys in three IFNs. In particular, girls showed greater within-network connectivity in two motor networks with more alcohol consumption, and these effects were mediated by sensation-seeking only in girls. Our results implied that drinking might attenuate the naturally diminishing sexual differences by disrupting the maturation of network efficiency more severely in girls. The sex-alcohol-dose effect might explain why women are at higher risk of alcohol-related health and psychosocial consequences than men.
📖 Papers frequently viewed together
375 Citations
99 Citations
25 Citations
#1Jalmar Teeuw (UU: Utrecht University)H-Index: 6
#2Rachel M. Brouwer (UU: Utrecht University)H-Index: 37
Last. Hilleke E. Hulshoff Pol (UU: Utrecht University)H-Index: 96
view all 9 authors...
Abstract The human brain is active during rest and hierarchically organized into intrinsic functional networks. These functional networks are largely established early in development, with reports of a shift from a local to more distributed organization during childhood and adolescence. It remains unknown to what extent genetic and environmental influences on functional connectivity change throughout adolescent development. We measured functional connectivity within and between eight cortical ne...
17 CitationsSource
#1Vaidehi Natu (Stanford University)H-Index: 16
#2Jesse Gomez (Stanford University)H-Index: 13
Last. Kalanit Grill-Spector (Stanford University)H-Index: 47
view all 11 authors...
Human cortex appears to thin during childhood development. However, the underlying microstructural mechanisms are unknown. Using functional magnetic resonance imaging (fMRI), quantitative MRI (qMRI), and diffusion MRI (dMRI) in children and adults, we tested what quantitative changes occur to gray and white matter in ventral temporal cortex (VTC) from childhood to adulthood, and how these changes relate to cortical thinning. T1 relaxation time from qMRI and mean diffusivity (MD) from dMRI provid...
82 CitationsSource
#1Alexandre RoutierH-Index: 11
#2Arnaud MarcouxH-Index: 3
Last. Olivier ColliotH-Index: 41
view all 14 authors...
2,592 CitationsSource
#1Qingyu Zhao (Stanford University)H-Index: 8
#2Dongjin Kwon (Stanford University)H-Index: 18
Last. Kilian M. Pohl (SRI: SRI International)H-Index: 27
view all 7 authors...
: Increasing numbers of neuroimaging studies are acquiring data to examine changes in brain architecture by investigating intrinsic functional networks (IFN) from longitudinal resting-state functional MRI (rs-fMRI). At the subject level, these IFNs are determined by cross-sectional procedures, which neglect intra-subject dependencies and result in suboptimal estimates of the networks. Here, a novel longitudinal approach simultaneously extracts subject-specific IFNs across multiple visits by expl...
4 CitationsSource
#1Ehsan Adeli (Stanford University)H-Index: 22
#2Dongjin Kwon (Stanford University)H-Index: 18
Last. Kilian M. Pohl (SRI: SRI International)H-Index: 27
view all 7 authors...
Abstract Human Immunodeficiency Virus (HIV) infection continues to have major adverse public health and clinical consequences despite the effectiveness of combination Antiretroviral Therapy (cART) in reducing HIV viral load and improving immune function. As successfully treated individuals with HIV infection age, their cognition declines faster than reported for normal aging. This phenomenon underlines the importance of improving long-term care, which requires a better understanding of the impac...
13 CitationsSource
#1Wenjing Cai (University of the Sciences)H-Index: 5
#2Evgenia I. Lysova (VU: VU University Amsterdam)H-Index: 8
Last. Bart Bossink (VU: VU University Amsterdam)H-Index: 22
view all 4 authors...
While scholars acknowledge the critical role of employee innovative work behavior (IWB) in facilitating organizational innovation in the high-tech industry, current knowledge is far from complete to specifically paint a clear picture of how to evoke employee IWB in Chinese high-tech industry sectors. Drawing on a dynamic componential model of creativity and innovation, this study proposes and tests a moderated mediation model that examines the positive influence of servant leadership on employee...
46 CitationsSource
#1Sien Hu (Yale University)H-Index: 24
#2Jaime S. Ide (Yale University)H-Index: 22
Last. Chiang-shan R. LiH-Index: 58
view all 8 authors...
Abstract Alcohol misuse is associated with dysfunction of the amygdala-prefrontal cortical circuit. The amygdala and its cortical targets show decreased activity during a variety of task challenges in individuals engaged in problem drinking. On the other hand, it is less clear how amygdala resting state functional connectivity (rsFC) may be altered in association with alcohol misuse and whether such changes are restricted to prefrontal cortical structures. Further, the influences of comorbid sub...
23 CitationsSource
#1Eva M. Müller-Oehring (Stanford University)H-Index: 28
#2Dongjin Kwon (Stanford University)H-Index: 18
Last. Kilian M. Pohl (SRI: SRI International)H-Index: 27
view all 20 authors...
Author(s): Muller-Oehring, Eva M; Kwon, Dongjin; Nagel, Bonnie J; Sullivan, Edith V; Chu, Weiwei; Rohlfing, Torsten; Prouty, Devin; Nichols, B Nolan; Poline, Jean-Baptiste; Tapert, Susan F; Brown, Sandra A; Cummins, Kevin; Brumback, Ty; Colrain, Ian M; Baker, Fiona C; De Bellis, Michael D; Voyvodic, James T; Clark, Duncan B; Pfefferbaum, Adolf; Pohl, Kilian M | Abstract: The transition from adolescent to adult cognition and emotional control requires neurodevelopmental maturation likely involvin...
18 CitationsSource
#1Raluca PetricanH-Index: 11
#2Margot J. Taylor (U of T: University of Toronto)H-Index: 60
Last. Cheryl L. Grady (U of T: University of Toronto)H-Index: 109
view all 3 authors...
Abstract The human brain's intrinsic functional architecture reflects behavioural history and can help elucidate the neural mechanisms underlying age-related cognitive changes. To probe this issue, we used resting state (N = 586) and behavioural (N = 255) data from a lifespan sample and tested the interactions among ten intrinsic neural systems, derived from a well-established whole-brain parcellation. Our results revealed three distinguishable profiles, whose expression strengthened with increa...
18 CitationsSource
#1Megan E. Patrick (UM: University of Michigan)H-Index: 58
#2Yvonne M. Terry-McElrath (UM: University of Michigan)H-Index: 28
Last. Bethany C. Bray (PSU: Pennsylvania State University)H-Index: 24
view all 4 authors...
Abstract Objective Using a national sample of young adults, this study identified latent classes of alcohol use including high-intensity drinking (10+ drinks) from ages 18 to 25/26, and explored associations between time-invariant covariates measured at age 18 and class membership. Method Longitudinal data from the national Monitoring the Future study were available for 1078 individuals (51% female) first surveyed as 12th grade students in 2005–2008, and followed through modal age 25/26. Repeate...
5 CitationsSource
Cited By0
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2R. J. Loughnan (UCSD: University of California, San Diego)H-Index: 4
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
view all 0 authors...
It is important to understand the molecular determinants for microstructures of human brain. However, past genome-wide association studies (GWAS) on microstructures of human brain have had limited results due to methodological constraints. Here, we adopt advanced imaging processing methods and multivariate GWAS on two large scale imaging genetic datasets (UK Biobank and Adolescent Brain Cognitive Development study) to identify and validate key genetic association signals. We discovered 503 uniqu...
#1Jiashuai Zhang (Fudan University)
#2Xiayun Zuo (Fudan University)H-Index: 11
Last. Chaohua Lou (Fudan University)H-Index: 15
view all 6 authors...
Adolescent alcohol use was a major social and public health concern given its negative impacts. Previous studies indicated gender role attitudes (GRA) were associated with alcohol use; however, few...
#1Delin Sun (Veterans Health Administration)H-Index: 11
#2Viraj Adduru (Veterans Health Administration)H-Index: 4
Last. Rajendra A. Morey (Duke University)H-Index: 34
view all 16 authors...
Objective: Cortical thickness changes dramatically during development and is influenced by adolescent drinking. However, previous findings have been inconsistent and limited by region-of-interest approaches that are underpowered because they do not conform to the underlying heterogeneity from the effects of alcohol. Methods: Adolescents (n=657; 12-22 years at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) who endorsed little to no alcohol use at ba...