Addiction Biology
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#1Weiran ZhouH-Index: 1
#2Yi-Ming Wang (Hangzhou Normal University)
Last. Guangheng Dong (Hangzhou Normal University)H-Index: 27
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BACKGROUND Craving-related brain responses have been associated with the emergence and maintenance of addictions. However, little is known about brain network organizations underlying cravings in internet gaming disorder (IGD). METHODS Sixty-six IGD subjects and 61 matched individuals with recreational game use (RGU) were scanned while performing a cue-craving task. A recently developed whole-brain analysis approach, connectome-based predictive modelling (CPM) with leave-one-out cross-validation...
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#1Ruyan Wu (YZU: Yangzhou University)H-Index: 3
#2Jianfeng Liu (UB: University at Buffalo)H-Index: 68
Last. Jun-Xu Li (UB: University at Buffalo)H-Index: 30
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Nicotine addiction is a leading avoidable brain disorder globally. Although nicotine induces a modest reinforcing effect, which is important for the initial drug use, the transition from nicotine use to nicotine addiction involves the mechanisms responsible for the negative consequences of drug abstinence. Recent study suggested that trace amine-associated receptor 1 (TAAR1) is a promising pharmacological target for the modulation of positive reinforcing effects of nicotine. However, whether TAA...
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#1Eric Vornholt (VCU: Virginia Commonwealth University)H-Index: 3
#2John Drake (A&M: Texas A&M University)H-Index: 2
Last. Vladimir I. VladimirovH-Index: 23
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Our lab and others have shown that chronic alcohol use leads to gene and miRNA expression changes across the mesocorticolimbic (MCL) system. Circular RNAs (circRNAs) are noncoding RNAs that form closed-loop structures and are reported to alter gene expression through miRNA sequestration, thus providing a potentially novel neurobiological mechanism for the development of alcohol dependence (AD). Genome-wide expression of circRNA was assessed in the nucleus accumbens (NAc) from 32 AD-matched cases...
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#1Patrick Trotzke (University of Duisburg-Essen)H-Index: 13
#2Katrin StarckeH-Index: 19
Last. Matthias Brand (University of Duisburg-Essen)H-Index: 68
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BACKGROUND AND AIMS Buying-shopping disorder (BSD) is a clinical condition in which individuals lose control over their buying behaviour and continue buying despite negative consequences such as indebtedness, loss of family and friends. BSD has been considered a behavioural addiction and first studies provide evidence for cue-reactivity and craving as potential pathomechanisms. The current study aimed at investigating neural correlates of cue-reactivity and craving in individuals with BSD using ...
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#1Molly Carlyle (University of Exeter)H-Index: 3
Last. Celia J. A. Morgan (University of Exeter)H-Index: 47
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Experiences of childhood trauma (abuse and neglect) are disproportionately higher in those with opioid use disorder (OUD). Childhood trauma may affect the reinforcing and rewarding properties of opioid drugs and responses to pain, potentially via developmental changes to the endogenous opioid system. This has been supported by preclinical research, yet this has not been investigated in non-addicted humans. Physically healthy participants with either a history of severe childhood trauma or no pre...
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#1Víctor Costumero (James I University)H-Index: 12
#2Patricia Rosell Negre (James I University)
Last. Alfonso Barrós-Loscertales (James I University)H-Index: 24
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Previous investigations have used global graph theory measures in order to disentangle the complexity of the neural reorganizations occurring in cocaine use disorder (CUD). However, how these global topological alterations map into individual brain network areas remains unknown. In this study, we used resting state functional magnetic resonance imaging (fMRI) data to investigate node-level topological dysfunctions in CUD. The sample was composed of 32 individuals with CUD and 32 healthy controls...
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#1Patrick Bach (Heidelberg University)H-Index: 12
#2Iris Reinhard (Heidelberg University)H-Index: 26
Last. Falk Kiefer (Heidelberg University)H-Index: 60
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Over the last decades, the assessment of alcohol cue-reactivity gained popularity in addiction research, and efforts were undertaken to establish neural biomarkers. This attempt however depends on the reliability of cue-induced brain activation. Thus, we assessed test-retest reliability of alcohol cue-reactivity and its implications for imaging studies in addiction. We investigated test-retest reliability of alcohol cue-induced brain activation in 144 alcohol-dependent patients over 2 weeks. We ...
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#1Teng He (Nanjing University of Chinese Medicine)
#2Nanqin Li (Nanjing University of Chinese Medicine)H-Index: 1
Last. Xiaowei Guan (Nanjing University of Chinese Medicine)H-Index: 1
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Methamphetamine (METH) elicits endogenous glutamate (Glu) in the brain, which could partially explain METH-induced memory deficits. Here, we investigated the therapeutic effects of electroacupuncture (EA) on spatial memory deficits in METH withdrawal mice and its potential synaptic mechanisms. We found that EA at acupoints 'Baihui' and 'Yintang' ameliorated the impaired spatial memory in METH withdrawal mice. In parallel, EA attenuated the Glu levels in vivo and suppressed the neuronal activitie...
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#1Tingwei Wang (Jiangnan University)H-Index: 1
#2Chunyang Xu (Soochow University (Suzhou))
Last. Xiulan Sun (Jiangnan University)H-Index: 27
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Methamphetamine (METH) abuse has become a global public health problem. However, the potential mechanisms involving METH-induced metabolic disorders have thus far remained poorly understood. Metabolomics can provide a clue for the cause of apparent changes and consequently be used to investigate the METH-induced dysregulation of metabolite expression and the mechanism of metabolic disorder mechanism. This laboratory investigation included 80 METH abusers and 80 healthy people. The serum metaboli...
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#1Megan M. Wickens (TU: Temple University)H-Index: 2
#2Julia M Kirkland (TU: Temple University)H-Index: 1
Last. Lisa A. Briand (TU: Temple University)H-Index: 21
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Disruption of prefrontal glutamate receptor interacting protein (GRIP), which anchors GluA2-containing AMPA receptors (AMPARs) into the synaptic membrane, potentiates cue-induced cocaine seeking in both males and females. Protein interacting with C kinase 1 (PICK1) plays an opposing role to that of GRIP, removing AMPARs from the synapse. Consistent with our hypothesis that disruption of PICK1 in the mPFC would lead to a decrease in addiction-like behaviour, we found that conditional deletion of ...
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