Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions

Published on Feb 1, 2021in Cytokine & Growth Factor Reviews5.982
· DOI :10.1016/J.CYTOGFR.2020.05.004
Katarzyna Dominika Sluzalska1
Estimated H-index: 1
(UWr: University of Wrocław),
Jakub Sławski3
Estimated H-index: 3
(UWr: University of Wrocław)
+ 3 AuthorsMalgorzata Zakrzewska17
Estimated H-index: 17
(UWr: University of Wrocław)
Sources
Abstract
Abstract Fibroblast growth factors 1 and2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. These unique features, as well as the role of the intracellular pool of FGF1 and FGF2, are far from being fully understood. An increasing number of reports address this problem, focusing on the intracellular interactions of FGF1 and 2. Here, we summarize the current state of knowledge of the FGF1 and FGF2 binding partners inside the cell and the possible role of these interactions. The partner proteins are grouped according to their function, including proteins involved in secretion, cell signaling, nucleocytoplasmic transport, binding and processing of nucleic acids, ATP binding, and cytoskeleton assembly. An in-depth analysis of the network of these binding partners could indicate novel, non-classical functions of FGF1 and FGF2 and uncover an additional level of a fine control of the well-known FGF-regulated cellular processes.
📖 Papers frequently viewed together
163 Citations
131 Citations
9 Citations
References285
Newest
#1Konstantinos Karakostis (University of Paris)H-Index: 10
#2Robin Fåhraeus (Umeå University)H-Index: 27
Structured RNA regulatory motifs exist from the prebiotic stages of the RNA world to the more complex eukaryotic systems. In cases where a functional RNA structure is within the coding sequence a selective pressure drives a parallel co-evolution of the RNA structure and the encoded peptide domain. The p53-MDM2 axis, describing the interactions between the p53 tumor suppressor and the MDM2 E3 ubiquitin ligase, serves as particularly useful model revealing how secondary RNA structures have co-evol...
5 CitationsSource
#1Yi Li (ZJU: Zhejiang University)H-Index: 3
#2Meng-Chen Zhang (ZJU: Zhejiang University)H-Index: 2
Last. Xue-Qun Chen (ZJU: Zhejiang University)H-Index: 14
view all 10 authors...
The common understanding of p53 function is a genome guardian, which is activated by diverse stresses stimuli and mediates DNA repair, apoptosis and cell cycle arrest. Increasing evidence has demonstrated p53 new cellular functions involved in abundant endocrine and metabolic response for maintaining homeostasis. However, TP53 is frequently mutant in human cancers, and the mutant p53 (Mut-p53) turns to an “evil” cancer-assistant. Mut-p53-induced epithelial-mesenchymal transition (EMT) plays a cr...
9 CitationsSource
#1Miseon Lee (UOU: University of Ulsan)H-Index: 6
#2In Ah Park (UOU: University of Ulsan)H-Index: 15
Last. Hee Jin Lee (UOU: University of Ulsan)H-Index: 26
view all 6 authors...
BACKGROUND: Most triple-negative breast cancers (TNBCs) have a high histologic grade, are associated with high endoplasmic stress, and possess a high frequency of TP53 mutations. TP53 missense mutations lead to the production of mutant p53 protein and usually show high levels of p53 protein expression. Tumor-infiltrating lymphocytes (TILs) accumulate as part of the anti-tumor immune response and have a strong prognostic and predictive significance in TNBC. We aimed to elucidate the association b...
3 CitationsSource
#1Chuanzhen Yang (PKU: Peking University)H-Index: 4
#2Weicheng Zang (PKU: Peking University)H-Index: 2
Last. Xiaofeng Zheng (PKU: Peking University)H-Index: 21
view all 6 authors...
: Ribosomal proteins are the building blocks of ribosome biogenesis. Beyond their known participation in ribosome assembly, the ribosome-independent functions of ribosomal proteins are largely unknown. Here, using immunoprecipitation, subcellular fractionation, His-ubiquitin pulldown, and immunofluorescence microscopy assays, along with siRNA-based knockdown approaches, we demonstrate that ribosomal protein L6 (RPL6) directly interacts with histone H2A and is involved in the DNA damage response ...
13 CitationsSource
#1Eleni Dimou (Heidelberg University)H-Index: 11
#2Katia CosentinoH-Index: 10
Last. Walter Nickel (Heidelberg University)H-Index: 45
view all 12 authors...
FGF2 is exported from cells by an unconventional secretory mechanism. Here, we directly visualized individual FGF2 membrane translocation events at the plasma membrane using live cell TIRF microscopy. This process was dependent on both PI(4,5)P 2 –mediated recruitment of FGF2 at the inner leaflet and heparan sulfates capturing FGF2 at the outer plasma membrane leaflet. By simultaneous imaging of both FGF2 membrane recruitment and the appearance of FGF2 at the cell surface, we revealed the kineti...
13 CitationsSource
#2Anne Nehlig (Université Paris-Saclay)H-Index: 4
Last. Clara Nahmias (French Institute of Health and Medical Research)H-Index: 32
view all 15 authors...
Purpose The identification of molecular biomarkers for classification of breast cancer is needed to better stratify the patients and guide therapeutic decisions. The aim of this study was to investigate the value of MAPRE1 gene encoding microtubule-end binding proteins EB1 as a biomarker in breast cancer and evaluate whether combinatorial expression of MAPRE1 and MTUS1 gene encoding EB1-negative regulator ATIP3 may improve breast cancer diagnosis and prognosis.
10 CitationsSource
#1Tamara A. Potapova (Stowers Institute for Medical Research)H-Index: 14
#2Jennifer L. Gerton (Stowers Institute for Medical Research)H-Index: 34
The nucleolus constitutes a prominent nuclear compartment, a membraneless organelle that was first documented in the 1830s. The fact that specific chromosomal regions were present in the nucleolus was recognized by Barbara McClintock in the 1930s, and these regions were termed nucleolar organizing regions, or NORs. The primary function of ribosomal DNA (rDNA) is to produce RNA components of ribosomes. Yet, ribosomal DNA also plays a pivotal role in nuclear organization by assembling the nucleolu...
17 CitationsSource
#1Xiaoyang Zhao (Fudan University)H-Index: 2
#2Vikash Reebye (Imperial College London)H-Index: 14
Last. Kai-Wen Huang (NTU: National Taiwan University)H-Index: 18
view all 9 authors...
Hepatocellular carcinoma (HCC) is generally accompanied by high mortality and low cure rate. CCAAT enhancer-binding proteins (CEBPs) are transcriptional regulators that play a key role in maintaining liver function. Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-stranded RNAs that enhance target gene expression at the transcriptional level. In this report, we activate CEPBA with saRNAs and suppress CEBPB with siRNAs in cells that represent t...
4 CitationsSource
#1Nora KoryH-Index: 12
#2Gregory A. WyantH-Index: 11
Last. David M. SabatiniH-Index: 138
view all 12 authors...
INTRODUCTION One-carbon metabolism generates the one-carbon units required to synthesize many critical metabolites, including nucleotides, amino acids, and lipids. The pathway has cytosolic and mitochondrial branches, and a key step is the entry, through an unknown mechanism, of serine into mitochondria, where it is converted into glycine and formate. In dividing mammalian cells, the mitochondrial catabolism of serine supplies most of the one-carbon units needed for biosynthesis. Indeed, many ca...
68 CitationsSource
#1Farhadul IslamH-Index: 19
#2Stephanie ChaousisH-Index: 1
Last. Alfred King-Yin LamH-Index: 59
view all 5 authors...
FAM134B is an autophagy regulator of endoplasmic reticulum and acts as a cancer suppressor in colon cancer. However, the molecular signaling pathways by which FAM134B interacts within colon carcinogenesis is still unknown. Herein, this study aims to determine the interacting partners of FAM134B for the first time in colon cancer and to explore the precise location of FAM134B in cancer signalling pathways. Liquid chromatography coupled with tandem mass spectrometry (LC‐MS/MS) followed by anti‐FAM...
9 CitationsSource
Cited By2
Newest
#1Dai KoguchiH-Index: 3
#2Kazumasa MatsumotoH-Index: 35
Last. Masatsugu IwamuraH-Index: 23
view all 8 authors...
Data regarding expression levels of AHNAK2 in bladder cancer (BCa) have been very scarce. We retrospectively reviewed clinical data including clinicopathological features in 120 patients who underwent radical cystectomy (RC) for BCa. The expression levels of AHNAK2 in the specimens obtained by RC were classified as low expression (LE) or high expression (HE) by immunohistochemical staining. Statistical analyses were performed to compare associations between the two AHNAK2 expression patterns and...
Source
#1Érica Resende Oliveira (UFG: Universidade Federal de Goiás)H-Index: 4
#2Lei Nie (Xinyang Normal University)H-Index: 16
Last. Amin Shavandi (ULB: Université libre de Bruxelles)H-Index: 17
view all 7 authors...
Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues. Although recent studies on developing novel growth facto...
1 CitationsSource