Abstract 188: Prrx1 Marks Ventral Fibroblasts With Increased Fibrogenic Potential

Purpose: Skin fibrosis amounts to significant morbidity due to the prevalence of trauma and burn injuries. Fibroblasts are chiefly responsible for extracellular matrix (ECM) deposition in the skin and are increasingly recognized to be a heterogeneous population comprised of multiple subpopulations with distinct functions and scarring propensity. While anatomic and embryonic origin are known to determine fibroblast heterogeneity, most prior work...