Michael T. Longaker
Stanford University
AnatomyEndocrinologySurgeryPathologyCellular differentiationStromal cellRegeneration (biology)Adipose tissueFetusExtracellular matrixMesenchymal stem cellCraniosynostosisWound healingFibroblastFibrosisStem cellCancer researchMedicineBiologyCell biology
1,225Publications
135H-index
46.2kCitations
Publications 1234
Newest
#1Ruth Tevlin (Stanford University)H-Index: 15
#2Michael T. Longaker (Stanford University)H-Index: 135
Last. Derrick C. Wan (Stanford University)H-Index: 37
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Significance By 2030, there will be over 4 million radiation-treated cancer survivors living in the US. Irradiation triggers inflammation, fibroblast activation, and extracellular matrix deposition in addition to reactive oxygen species (ROS) generation, leading to a chronic inflammatory response. Radiation-induced fibrosis (RIF) is a progressive pathology resulting in skin pigmentation, reduced elasticity, ulceration and dermal thickening, cosmetic deformity, pain, and the need for reconstructi...
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#1Heather E. desJardins-Park (Stanford University)H-Index: 7
#2Shamik Mascharak (Stanford University)H-Index: 7
Last. Derrick C. Wan (Stanford University)H-Index: 37
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In the fields of oral and craniomaxillofacial surgery, regeneration of multiple tissue types - including bone, skin, teeth, and mucosal soft tissue - is often a desired outcome. However, limited endogenous capacity for regeneration, as well as predisposition of many tissues to fibrotic healing, may prevent recovery of normal form and function for patients. Recent basic science research has advanced our understanding of molecular and cellular pathways of repair in the oral/craniofacial region and...
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#1Shamik Mascharak (Stanford University)H-Index: 7
#2Heather E. desJardins-Park (Stanford University)H-Index: 7
Last. Michael T. Longaker (Stanford University)H-Index: 135
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Skin scarring, the end result of adult wound healing, is detrimental to tissue form and function. Engrailed-1 lineage-positive fibroblasts (EPFs) are known to function in scarring, but Engrailed-1 lineage-negative fibroblasts (ENFs) remain poorly characterized. Using cell transplantation and transgenic mouse models, we identified a dermal ENF subpopulation that gives rise to postnatally derived EPFs by activating Engrailed-1 expression during adult wound healing. By studying ENF responses to sub...
2 CitationsSource
#1Evan J. Fahy (Stanford University)
#2Michelle GriffinH-Index: 23
Last. Derrick C. WanH-Index: 37
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ABSTRACT The primary organ systems and tissues concerning plastic and reconstructive surgery include the integument, vasculature, subcutis, and peripheral nerves, because these may individually or collectively be injured requiring reconstruction, or indeed be used in reconstruction themselves through grafts, flaps, or anastomoses. Adrenergic receptors are present throughout these anatomic components on the vasculature, adipose, platelets, immune cells, keratinocytes, melanocytes, fibroblasts, pe...
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#1Deshka S. Foster (Stanford University)H-Index: 10
#2Michael JanuszykH-Index: 32
Last. Michael T. LongakerH-Index: 135
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In the skin, tissue injury results in fibrosis in the form of scars composed of dense extracellular matrix deposited by fibroblasts. The therapeutic goal of regenerative wound healing has remained elusive in part because principles of fibroblast programming and adaptive response to injury remain incompletely understood. Here, we present a multimodal -omics platform for the comprehensive study of cell populations in complex tissue, which has allowed us to characterize the cells involved in wound ...
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#1Zeshaan N. Maan (Stanford University)H-Index: 25
#2Michael S. Hu (Stanford University)H-Index: 24
Last. Geoffrey C. Gurtner (Stanford University)H-Index: 82
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CXC chemokine ligand 12 (CXCL12; stromal cell-derived factor 1 [SDF-1]), primarily known for its role in embryogenesis and hematopoiesis, has also been implicated in tumor biology and neovascularization. However, its specific role and mechanism of action remain poorly understood. We previously demonstrated that CXCL12 expression is Hypoxia-Inducible Factor (HIF)-1 responsive. Here we use a conditional CXCL12 knockout mouse to show that endothelial-specific deletion of CXCL12 (eKO) does not affec...
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#2Michelle GriffinH-Index: 23
Last. Natalina Quarto (University of Naples Federico II)H-Index: 27
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Mesenchymal stem cells (MSCs) have been repeatedly shown to be a valuable source for cell-based therapy in regenerative medicine, including bony tissue repair. However, engraftment at the injury site is poor. Recently, it has been suggested that MSCs and other cells act through a paracrine signaling mechanism. Exosomes are nanostructures that have been implicated in this process. They carry DNA, RNA, proteins, and lipids and play an important role in cell-to-cell communication directly modulatin...
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The purpose of this study was to determine the feasibility of using mouse models for translational study of flexor tendon repair and reconstruction. Methods Quantitative data detailing the gross anatomy, biomechanical characteristics, and microscopic structure of the deep digit flexor tendon (DDF) of the mouse hindpaw were obtained. Histological characterization of the DDF and the anatomy of the digit in the mouse hindpaw are detailed. Biomechanical testing determined the load-to-failure, stress...
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#1Michael S. Hu (Stanford University)H-Index: 24
#1Michael S. Hu (Stanford University)H-Index: 6
Last. Michael T. LongakerH-Index: 135
view all 19 authors...
Objective:The aim of this study was to determine the interaction of full thickness excisional wounds and tumors in vivo.Summary of Background Data:Tumors have been described as wounds that do not heal due to similarities in stromal composition. On the basis of observations of slowed tumor growth aft
1 CitationsSource
#1Harsh N. Shah (Stanford University)H-Index: 2
#2Ruth Ellen Jones (Stanford University)H-Index: 8
Last. Michael T. Longaker (Stanford University)H-Index: 135
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Background Bone retains regenerative potential into adulthood, and surgeons harness this plasticity during distraction osteogenesis. The underlying biology governing bone development, repair, and regeneration is divergent between the craniofacial and appendicular skeleton. Each type of bone formation is characterized by unique molecular signaling and cellular behavior. Recent discoveries have elucidated the cellular and genetic processes underlying skeletal development and regeneration, providin...
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