The Dual Role of Serotonin in Colorectal Cancer

Both brain and peripheral cells can synthesize 5-HT from the essential amino acid tryptophan, although intestinal enteroendocrine cells produce the most substantial amount of this hormone in the human body. The serotonergic system encompasses a range of elements required for its synthesis, storage, release, transport, signaling, and degradation, from which it modulates essential functions in keeping with the body homeostasis. Genetic,...