Trends in Endocrinology and Metabolism
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#1Devanshi Mishra (IITD: Indian Institute of Technology Delhi)H-Index: 2
#2Chinmoy S. Dey (IITD: Indian Institute of Technology Delhi)H-Index: 23
Protein kinase C alpha (PKCα) is known to participate in various signaling pathways due to its ubiquitous and dynamic characteristics. Previous studies report that PKCα abrogates peripheral insulin resistance, and recent publications show that it takes part in regulating Alzheimer's disease (AD). Based on evidence in the literature, we have highlighted how many of the substrates of PKCα in its signal transduction cascades are common in AD and diabetes and may have the capability to regulate both...
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#1Pomme I. H. G. Simons (UM: Maastricht University)H-Index: 1
#2Olivier Valkenburg (UM: Maastricht University)
Last. Martijn C. G. J. Brouwers (UM: Maastricht University)H-Index: 20
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Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study has provided new insights at the population level. Thorough study of genetic variants affecting serum SHBG has identified de novo lipogenesis as one of the mechanistic links between the metabolic syndrome and reduced serum SHBG levels in humans. Furthermore, careful deduction of...
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#1Madeline Graham (Wellesley College)
#2William G. Herbert (Mayo Clinic)
Last. Marc J. Tetel (Wellesley College)H-Index: 26
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This review discusses the interactions of steroids with the gut and vaginal microbiomes within each life phase of adult women and the implications for women's health. Each phase of a woman's life is characterized by distinct hormonal states which drive overall physiology of both host and commensal microbes. These host-microbiome interactions underlie disease pathology in disorders that affect women across their lifetime, including bacterial vaginosis, gestational diabetes, polycystic ovary syndr...
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#1Jia Liang Sun-Wang (University of Barcelona)H-Index: 2
Last. Antonio Zorzano (University of Barcelona)H-Index: 92
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Type 2 diabetes mellitus (T2DM) is a global health challenge. Therefore, understanding the molecular mechanisms underlying the pathophysiology of T2DM is key to improving current therapies. Loss of protein homeostasis leads to the accumulation of damaged proteins in cells, which results in tissue dysfunction. The elimination of damaged proteins occurs through the ubiquitin-proteasome system (UPS) and autophagy. In this review, we describe the mutual regulation between the UPS and autophagy and t...
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#1Matthew Wortham (UCSD: University of California, San Diego)H-Index: 9
#2Maike Sander (UCSD: University of California, San Diego)H-Index: 54
Pancreatic β-cells secrete insulin commensurate to circulating nutrient levels to maintain normoglycemia. The ability of β-cells to couple insulin secretion to nutrient stimuli is acquired during a postnatal maturation process. In mature β-cells the insulin secretory response adapts to changes in nutrient state. Both β-cell maturation and functional adaptation rely on the interplay between extracellular cues and cell type-specific transcriptional programs. Here we review emerging evidence that d...
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#1John Henderson (Northumbria University)H-Index: 5
#2Steven O'Reilly (Durham University)H-Index: 25
The metabolic shift that cancer cells undergo towards aerobic glycolysis was identified as a defining feature in tumours almost 100 years ago; however, it has only recently become apparent that similar metabolic reprogramming is a key feature in other diseases - with fibrosis now entering the fray. In this perspective, an overview of the recent evidence implicating increased glycolysis and glutaminolysis as mediators of fibrosis is presented, with a particular emphasis on the novel therapeutic p...
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#1Philippe Icard (French Institute of Health and Medical Research)H-Index: 4
#2Marco Alifano (University of Paris)H-Index: 55
Last. Luca Simula (University of Paris)
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We propose that fructose-1,6-bisphosphate (F-1,6-BP) promotes a feedback loop between phosphofructokinase-1 (PFK1), phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), and PFK2/PFKFB3, which enhances aerobic glycolysis and sustains effector T (Teff) cell activation, while oxidative metabolism is concomitantly downregulated. This regulation, promoted by low citrate and mitochondrial ATP synthesis, also sustains the Warburg effect in cancer cells.
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#1Amir Ajoolabady (College of Health Sciences, Bahrain)H-Index: 5
Last. Jun Ren (UW: University of Washington)H-Index: 99
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Ferroptosis is a form of regulated cell death modality associated with disturbed iron-homeostasis and unrestricted lipid peroxidation. Ample evidence has depicted an essential role for ferroptosis as either the cause or consequence for human diseases, denoting the likely therapeutic promises for targeting ferroptosis in the preservation of human health. Ferritinophagy, a selective form of autophagy, contributes to the initiation of ferroptosis through degradation of ferritin, which triggers labi...
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#1Juan Domínguez-Bendala (UM: University of Miami)H-Index: 21
#2Mirza Muhammad Fahd Qadir (Tulane University)H-Index: 8
Last. Ricardo L. Pastori (UM: University of Miami)H-Index: 24
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The application of single-cell analytic techniques to the study of stem/progenitor cell niches supports the emerging view that pancreatic cell lineages are in a state of flux between differentiation stages. For all their value, however, such analyses merely offer a snapshot of the cellular palette of the tissue at any given time point. Conclusions about potential developmental/regeneration paths are solely based on bioinformatics inferences. In this context, the advent of new techniques for the ...
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#1Nikolai Jaschke (TUD: Dresden University of Technology)H-Index: 2
#2Sophie Paehlig (TUD: Dresden University of Technology)
Last. Tilman D. Rachner (TUD: Dresden University of Technology)H-Index: 20
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Soluble mediators secreted by skeletal muscles (collectively referred to as myokines) exert systemic effects by signaling to distant organs. Rai et al. have now uncovered a muscle-to-central nervous system (CNS) signaling axis, which is engaged in response to proteostatic stress. These adaptations confer protection against pathological protein accumulation in the CNS, a hallmark of neurodegenerative diseases.
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Top fields of study
Endocrinology
Receptor
Diabetes mellitus
Hormone
Medicine
Biology
Cell biology