Trends in Endocrinology and Metabolism
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#1Qianhong Ye (CAU: China Agricultural University)H-Index: 6
#2Xiangzhou Zeng (CAU: China Agricultural University)H-Index: 6
Last. Xiangfang Zeng (CAU: China Agricultural University)H-Index: 24
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Metabolic regulation plays important roles in embryo development and uterine receptivity during early pregnancy, ultimately influencing pregnancy efficiency in mammals. The important roles of lipid metabolism during early pregnancy have not been fully understood. Here, we described the regulatory roles of phospholipid, sphingolipid, and cholesterol metabolism on early embryo development, implantation, and uterine receptivity through production of cannabinoids, prostaglandins, lysophosphatidic ac...
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#1Gabriella Milan (UNIPD: University of Padua)H-Index: 26
#2Scilla Conci (UNIPD: University of Padua)H-Index: 2
Last. Roberto Vettor (UNIPD: University of Padua)H-Index: 71
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We describe adipose stromal/stem cells (ASCs) in the structural/functional context of the adipose tissue (AT) stem niche (adiponiche), including cell-cell interactions and the microenvironment, and emphasize findings obtained in humans and in lineage-tracing models. ASCs have distinctive markers, 'colors', and anatomical 'locations' which influence their functions. Each adiponiche component can become impaired, thereby contributing to the pathological AT alterations seen in obesity and metabolic...
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#1Skylar R. Batty (UA: University of Arizona)
#2Paul Langlais (UA: University of Arizona)H-Index: 22
Microtubules (MT) have a role in the intracellular response to insulin stimulation and subsequent glucose transport by glucose transporter 4 (GLUT4), which resides in specialized storage vesicles that travel through the cell. Before GLUT4 is inserted into the plasma membrane for glucose transport, it undergoes complex trafficking through the cell via the integration of cytoskeletal networks. In this review, we highlight the importance of MT elements in insulin action in adipocytes through a summ...
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#1Anushna Sen (UIUC: University of Illinois at Urbana–Champaign)H-Index: 1
#2Sayeepriyadarshini Anakk (UIUC: University of Illinois at Urbana–Champaign)H-Index: 20
Nuclear receptors (NRs) are ligand-binding transcription factors that regulate gene networks and physiological responses. Often oxidative stress precedes the onset of liver diseases, and Nrf2 is a key regulator of antioxidant pathways. NRs crosstalk with Nrf2, since NR activation can influence the oxidative milieu by modulating reductive cellular processes. Diet and xenobiotics also regulate NR expression and activity, suggesting a feedback loop. Depending on the tissue context and cues, NRs eit...
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#1Cynthia M. Bulik (UNC: University of North Carolina at Chapel Hill)H-Index: 125
#2Ian M. Carroll (UNC: University of North Carolina at Chapel Hill)H-Index: 33
Last. Phil Mehler (University of Colorado Denver)
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Anorexia nervosa (AN) is a serious and often fatal illness. Despite decades of research, investigators have failed to adequately advance our understanding of the biological aspects of AN that could inform the development of effective interventions. Genome-wide association studies are revealing the important role of metabolic factors in AN, and studies of the gastrointestinal tract are shedding light on disruptions in enteric microbial communities and anomalies in gut morphology. In this opinion ...
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#1Thierry AlquierH-Index: 27
#2Catherine A. Christian-Hinman (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last. Nils J. Færgeman (University of Southern Denmark)H-Index: 45
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Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABAA receptor, and was thus termed diazepam binding inhibitor (DBI). Shortly after, an identical polypeptide was identified in liver by its ability to induce termination of fatty acid synthesis, and was named acyl-CoA binding protein (ACBP). Since then, ACBP/DBI has been studied in parallel without a clear and integrated understanding of its dual rol...
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#1Mansour Haidar (University of Hasselt)H-Index: 6
#2Melanie Loix (University of Hasselt)H-Index: 1
Last. Jerome J. A. Hendriks (University of Hasselt)H-Index: 26
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Lipophagy is the process of selective degradation of lipid droplets (LDs) by autophagy. Several studies have highlighted the importance of lipophagy in regulating cellular lipid levels in various tissues and disease conditions. In recent years, disruption of autophagy and accumulation of LDs have been reported as pathological hallmarks in several neurodegenerative and neuroinflammatory diseases, raising the question whether lipophagy is a process that is important in the progression of these dis...
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#1Susanne Keipert (Stockholm University)H-Index: 4
#2Mario Ost (Leipzig University)
Fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) are established as stress-responsive cytokines that can modulate energy balance by increasing energy expenditure or suppressing food intake, respectively. Despite their pharmacologically induced beneficial effects on obesity and comorbidities, circulating levels of both cytokines are elevated during obesity and related metabolic complications. On the other hand, endocrine crosstalk via FGF21 and GDF15 was also repor...
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Vitamin D is defined as a nutrient despite its rare occurrence in food. Vitamin D status is determined mainly by solar UV light action in skin. However, the strategy to combat vitamin D deficiency has been to increase oral intake of vitamin D in greater amounts than could be obtained from food. Persistent large intakes of vitamin D can cause hypercalcaemic toxicity. Although the amounts recommended to prevent deficiency are far less than those causing such toxicity, the possibility of other toxi...
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#1Alessio Molfino (Sapienza University of Rome)H-Index: 23
#2Giovanni Imbimbo (Sapienza University of Rome)H-Index: 2
Last. Maurizio Muscaritoli (Sapienza University of Rome)H-Index: 63
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Top fields of study
Endocrinology
Receptor
Diabetes mellitus
Hormone
Medicine
Biology
Cell biology