Selective Photokilling of Colorectal Tumors by Near-Infrared Photoimmunotherapy with a GPA33-Targeted Single-Chain Antibody Variable Fragment Conjugate.

Published on May 12, 2020in Molecular Pharmaceutics4.939
· DOI :10.1021/ACS.MOLPHARMACEUT.0C00210
Danfeng Wei1
Estimated H-index: 1
(Sichuan University),
Ze Tao7
Estimated H-index: 7
(Sichuan University)
+ 9 AuthorsXian Jiang10
Estimated H-index: 10
(Sichuan University)
Sources
Abstract
Antibody-based near-infrared photoimmunotherapy (NIR-PIT) is an attractive strategy for cancer treatment. Tumor cells can be selectively and efficiently killed by the targeted delivery of an antibo...
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References45
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#1Pui-Chi Lo (CityU: City University of Hong Kong)H-Index: 41
#2M. Salomé Rodríguez-Morgade (UAM: Autonomous University of Madrid)H-Index: 21
Last. Fabienne Dumoulin (GIT: Gebze Institute of Technology)H-Index: 24
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Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour site...
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#1Hisataka KobayashiH-Index: 83
#2Gary L. Griffiths (NIH: National Institutes of Health)H-Index: 47
Last. Peter L. ChoykeH-Index: 141
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Cancer treatment has been founded traditionally on the three approaches of surgery, radiation and chemotherapy with the latter recognized as the obvious systemic treatment approach applicable to disease that has spread. While significant progress has been made over nearly 100 years of developing systemic treatments, it remains clear that use of the toxic agents involved is a two-edged sword with normal organ toxicities always needing to be balanced with and against administration of relevant the...
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#1Hisataka Kobayashi (NIH: National Institutes of Health)H-Index: 12
#2Peter L. Choyke (NIH: National Institutes of Health)H-Index: 141
ConspectusThis Account is the first comprehensive review article on the newly developed, photochemistry-based cancer therapy near-infrared (NIR) photoimmunotherapy (PIT). NIR-PIT is a molecularly targeted phototherapy for cancer that is based on injecting a conjugate of a near-infrared, water-soluble, silicon-phthalocyanine derivative, IRdye700DX (IR700), and a monoclonal antibody (mAb) that targets an expressed antigen on the cancer cell surface. Subsequent local exposure to NIR light turns on ...
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#1CĂ©line Frochot (CNRS: Centre national de la recherche scientifique)H-Index: 36
#2Serge Mordon (Lille University of Science and Technology)H-Index: 58
Photodynamic therapy has become of interest in many European countries. Since, most of national authorities and all medical journals require the registration of the clinical study on the database C...
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#1Tadanobu Nagaya (NIH: National Institutes of Health)H-Index: 29
#2Shuhei Okuyama (NIH: National Institutes of Health)H-Index: 14
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Background Peritoneal dissemination (PD) of abdominal malignancies is a common form of metastasis and its presence signals a poor prognosis. New treatment is required for patients with PD. Near infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody–photo-absorber conjugate (APC). In this study, we investigate in vitro and in vivo efficacy of trastuzumab (tra)-IR700DX NIR-PIT on a human epidermal growth factor receptor type 2 (HER2)-positive gastric c...
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#1Albert Kim (TU: Temple University)H-Index: 9
#2Jiawei Zhou (Purdue University)H-Index: 8
Last. Babak Ziaie (Purdue University)H-Index: 39
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Photodynamic therapy (PDT) is a promising cancer treatment modality that can selectively target unresectable tumors through optical activation of cytotoxic agents, thus reducing many side effects associated with systemic administration of chemotherapeutic drugs. However, limited light penetration into most biological tissues have so far prevented its widespread adoption beyond dermatology and a few other oncological applications in which a fiber optic can be threaded to the desired locations via...
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#1Kazuhide Sato (Nagoya University)H-Index: 26
#2Kanta Ando (Hokkaido University)H-Index: 2
Last. Hisataka Kobayashi (NIH: National Institutes of Health)H-Index: 12
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Photochemical reactions can dramatically alter physical characteristics of reacted molecules. In this study, we demonstrate that near-infrared (NIR) light induces an axial ligand-releasing reaction, which dramatically alters hydrophilicity of a silicon phthalocyanine derivative (IR700) dye leading to a change in the shape of the conjugate and its propensity to aggregate in aqueous solution. This photochemical reaction is proposed as a major mechanism of cell death induced by NIR photoimmunothera...
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#1Freddie Bray (IARC: International Agency for Research on Cancer)H-Index: 126
#2Jacques Ferlay (IARC: International Agency for Research on Cancer)H-Index: 72
Last. Ahmedin Jemal (ACS: American Cancer Society)H-Index: 139
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This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions. There will be an estimated 18.1 million new cancer cases (17.0 million excluding nonmelanoma skin cancer) and 9.6 million cancer deaths (9.5 million excluding nonmelanoma skin cancer) in 2018. In both sexes combined, lung cancer...
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#1Chengqiong Mao (Wake Forest University)H-Index: 20
#2Ping Qu (Wake Forest University)H-Index: 1
Last. Xin Ming (Wake Forest University)H-Index: 25
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P-glycoprotein (Pgp) has been considered as a major cause of cancer multidrug resistance; however, clinical solutions to overcome this drug resistance do not exist despite the tremendous endeavors. The lack of cancer specificity is a main reason for clinical failure of conventional approaches. Targeted photodynamic therapy (PDT) is highly cancer specific by combining antibody targeting and locoregional light irradiation. We aimed to develop Pgp-targeted PDT using antibody–photosensitizer conjuga...
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#1Andrew M.D. Wolf (UVA: University of Virginia)H-Index: 20
#2Elizabeth T. H. Fontham (LSU: Louisiana State University)H-Index: 62
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: In the United States, colorectal cancer (CRC) is the fourth most common cancer diagnosed among adults and the second leading cause of death from cancer. For this guideline update, the American Cancer Society (ACS) used an existing systematic evidence review of the CRC screening literature and microsimulation modeling analyses, including a new evaluation of the age to begin screening by race and sex and additional modeling that incorporates changes in US CRC incidence. Screening with any one of...
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#1Kohei Matsuoka (Nagoya University)H-Index: 3
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Near infrared photoimmunotherapy (NIR-PIT) is a molecularly targeted treatment for cancers achieved by injecting a conjugate of IRDye700DX® (IR700), a water-soluble silicon phthalocyanine derivative in the near infrared, and a monoclonal antibody that targets cancer cell antigens. NIR-PIT is a highly specific treatment with few side effects that results in rapid immunogenic cell death. Despite it being a very effective and innovative therapy, there are a few challenges preventing full implementa...
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#1Hiroaki WakiyamaH-Index: 7
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Intraductal papillary mucinous neoplasms (IPMN) are common and one of the main precursor lesions of pancreatic ductal adenocarcinoma (PDAC). PDAC derived from an IPMN is called intraductal papillary mucinous carcinoma (IPMC) and defines a subgroup of patients with ill-defined specificities. As compared to conventional PDAC, IPMCs have been associated to clinical particularities and favorable pathological features, as well as debated outcomes. However, IPMNs and IPMCs include distinct subtypes of...
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Abstract In recent years, with the continuous development of cancer immunotherapy, the strategy of human beings against cancer has undergone tremendous changes. Among them, immune checkpoint inhibitors based on the immune "brake" mechanism, as an indispensable part of immunotherapy, have brought new dawn to cancer treatment. Humans have developed a variety of monoclonal antibodies against CTLA-4 and PD-1/PD-L1, which have shown significant therapeutic effects on various cancers, especially melan...
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Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed cancer treatment that uses an antibody-photoabsorber (IRDye700DX) conjugate (APC) that is activated by NIR light irradiation. In September 2020, the first APC and laser system were conditionally approved for clinical use in Japan. A major benefit of NIR-PIT is that only APC-bound cancer cells that are exposed to NIR light are killed by NIR-PIT; thus, minimal damage occurs in adjacent normal cells. These early trials have demonstrate...
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Abstract Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer-targeted treatment effected by a chemical conjugation between a photosensitiser (e.g. the NIR phthalocyanine dye IRDye700DX) and a cancer-targeting moiety (e.g. a monoclonal antibody, moAb). Delivery of a conjugate in vivo leads to accumulation at the tumour cell surface by binding to cell surface receptors or antigens. Upon deployment of focal NIR-light, irradiation of the conjugate results in a rapid, targeted cell death. Ho...
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Intraductal papillary mucinous neoplasm (IPMN) is a precancerous lesion of pancreatic cancer. Although there are 4 types of IPMN, among which intestinal-type IPMN is likely to progress into invasive cancer known as colloid carcinoma, no information regarding the involvement of the intestinal phenotype in the carcinogenesis of IPMN exists. The present study was conducted to explore how the intestinal differentiation system is maintained during the tumor progression of intestinal-type IPMN using s...
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Currently, photodynamic theranostic/therapy (PDT) is becoming a potential strategy for selectively imaging malignant sites and treating cancer as a non-invasive therapeutic method. Photosensitizers...
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