Exploring the scope of indole interaction with 1,2-dicarbonyl compounds

The 1,2-dicarbonyl compounds have received extensive attention due to their high reactivity and toxicity in vitro and in vivo. Availability of scavenging compounds may facilitate development of efficient strategies for their control. The concept of in situ generation of carbonyl trapping agents is an intriguing proposition and has been demonstrated with amino acid tryptophan. Ability of indole to undergo electrophilic aromatic substitution...