Coronavirus

Engineering

Biology

Diarrhea

Tissue tropism

Etiology

Virology

Middle East respiratory syndrome

Outbreak

Coronavirus disease 2019 (COVID-19)

Coronaviridae

Enteric fever

Porcine epidemic diarrhea virus

Tropism

Infectious disease (medical specialty)

Internal medicine

Acute diarrhea

Medicine

Transmission (telecommunications)

Virus

Pandemic

Disease

Typhoid fever

Epizootic

Electrical engineering

Pathology

Virus Research

Discovered in 2017, swine enteric alphacoronavirus (SeACoV), also known as swine acute diarrhea syndrome coronavirus (SADS-CoV) or porcine enteric alphacoronavirus (PEAV), is the fifth porcine CoV identified in diarrheal piglets. The presumed name "SADS-CoV" may not be appropriate since current studies have not provided strong evidence for high pathogenicity of the virus. SeACoV was the most recently recognized CoV of potential bat origin prior to the novel human severe acute respiratory syndrome CoV 2 (SARS-CoV-2), associated with the pandemic CoV disease 2019 (COVID-19). Although SeACoV is recognized as a regional epizootic virus currently, it possesses the most extensive cell species tropism in vitro among known CoVs. This review summarizes the emergence of SeACoV and updates the research progress made from 2017 to early 2020, mainly focusing on the etiology, epidemiology, evolutionary perspective, potential for interspecies transmission, pathogenesis and diagnosis.

Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): An update three years after its discovery