In reply to letter to the editor: radiomic feature analysis of pre-treatment FDG PET-CT for predicting outcome in anal squamous cell carcinoma.

Published on May 2, 2020in European Journal of Nuclear Medicine and Molecular Imaging7.081
· DOI :10.1007/S00259-020-04836-5
P. J. Brown1
Estimated H-index: 1
(Leeds Teaching Hospitals NHS Trust),
Peter Brown (Leeds Teaching Hospitals NHS Trust)+ 1 AuthorsAndrew Scarsbrook9
Estimated H-index: 9
(University of Leeds)
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#1P. J. Brown (Leeds Teaching Hospitals NHS Trust)H-Index: 1
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Purpose Incidence of anal squamous cell carcinoma (ASCC) is increasing, with curative chemoradiotherapy (CRT) as the primary treatment of non-metastatic disease. A significant proportion of patients have locoregional treatment failure (LRF), but distant relapse is uncommon. Accurate prognostication of progression-free survival (PFS) would help personalisation of CRT regimens. The study aim was to evaluate novel imaging pre-treatment features, to prognosticate for PFS in ASCC.
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Summary Chemoradiotherapy is the primary treatment for patients with squamous cell carcinoma of the anus, but variations in the reported outcomes have restricted between-study comparisons. Treatment-related morbidity is considerable; however, no trial has comprehensively quantified long-term side-effects or quality of life. Therefore, we established the first international health-care professional and patient consensus to develop a core outcome set, using the Core Outcome Measures in Effectivene...
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