Coronavirus

2019-20 coronavirus outbreak

Biology

Acquired immune system

Virology

Immunity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Outbreak

Coronavirus disease 2019 (COVID-19)

Immunology

Immune system

Infectious disease (medical specialty)

Medicine

Innate immune system

Disease

Pathology

The Journal of Experimental Medicine

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.

The many faces of the anti-COVID immune response