Nanoparticle

Biotechnology

Biology

Photodynamic therapy

Biomedical engineering

Metallurgy

Materials science

Nuclear magnetic resonance

Absorption (acoustics)

Medical physics

Radiation therapy

Nanodot

Radiology

Gadolinium

Singlet oxygen

In vivo

Physics

Nanotechnology

Organic chemistry

Nanomedicine

Oxygen

Optics

Fluorescence

Composite material

Rose bengal

Medicine

Chemistry

Advanced Materials

Combination therapy based on nanomedicine has gained momentum in oncology in recent years, offering superior safety and efficacy over monotherapies. It is critical to design theranostics that are composed of imaging and therapeutic agents already approved. Herein, gadolinium (Gd)–rose bengal coordination polymer nanodots (GRDs) are reported. The GRDs exhibit a unique absorption property and 7.7‐fold luminescence enhancement, as well as a 1.9‐fold increase in singlet oxygen generation efficiency over free rose bengal. Meanwhile, GRDs exhibit a twofold increase in r 1 relaxivity over gadopentetic acid (Gd‐DTPA) and have better X‐ray absorption ability than rose bengal alone. These excellent properties of the GRDs are verified both in vitro and in vivo. The combination of photodynamic therapy (PDT) and radiation therapy (RT) more significantly inhibits tumor growth than monotherapies (i.e., PDT or RT). This work offers a new route to designing and synthesizing Gd‐based nanotheranostics for image‐guided cancer therapy.

Gadolinium–Rose Bengal Coordination Polymer Nanodots for MR‐/Fluorescence‐Image‐Guided Radiation and Photodynamic Therapy