Drinking ‘Off’ the Clock: Effects of Binge Alcohol on the Skeletal Muscle Core Clock

Introduction Circadian rhythms are ~24‐hour oscillations generated by a transcription‐translation feedback loop known as the core molecular clock. The core clock is comprised of a positive arm, which includes the genes circadian locomotor output cycles kaput (Clock) and brain and muscle arnt‐like (Bmal1), and a negative arm, which includes period (Per)1/2/3 and cryptochrome (Cry)1/2. Several physiological processes are ‘Clock’ controlled, and...