N⁶-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression

Objective Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Thus far, most drugs have failed to significantly improve patient survival. N 6 -methyladenosine (m 6 A) plays an important role in the progression of PDAC, but its aberrant regulation driven by germline variants in human diseases remains unclear. Design We first performed an exome-wide association analysis in 518 PDAC patients with overall survival...