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Original paper

N6-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression

Gut23.00
Volume: 69, Issue: 12, Pages: 2180 - 2192
Published: Apr 20, 2020
Abstract
Objective Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Thus far, most drugs have failed to significantly improve patient survival. N 6 -methyladenosine (m 6 A) plays an important role in the progression of PDAC, but its aberrant regulation driven by germline variants in human diseases remains unclear. Design We first performed an exome-wide association analysis in 518 PDAC patients with overall survival...
Paper Details
Title
N6-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression
Published Date
Apr 20, 2020
Journal
Volume
69
Issue
12
Pages
2180 - 2192
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