Original paper
Cryo-EM structure of the Hedgehog release protein Dispatched
Abstract
The Hedgehog (Hh) signaling pathway controls embryonic development and adult tissue homeostasis in multicellular organisms. In Drosophila melanogaster, the pathway is primed by secretion of a dually lipid-modified morphogen, Hh, a process dependent on a membrane-integral protein Dispatched. Although Dispatched is a critical component of the pathway, the structural basis of its activity has, so far, not been described. Here, we describe a...
Paper Details
Title
Cryo-EM structure of the Hedgehog release protein Dispatched
Published Date
Apr 15, 2020
Journal
Volume
6
Issue
16