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Original paper

Cryo-EM structure of the Hedgehog release protein Dispatched

Volume: 6, Issue: 16
Published: Apr 15, 2020
Abstract
The Hedgehog (Hh) signaling pathway controls embryonic development and adult tissue homeostasis in multicellular organisms. In Drosophila melanogaster, the pathway is primed by secretion of a dually lipid-modified morphogen, Hh, a process dependent on a membrane-integral protein Dispatched. Although Dispatched is a critical component of the pathway, the structural basis of its activity has, so far, not been described. Here, we describe a...
Paper Details
Title
Cryo-EM structure of the Hedgehog release protein Dispatched
Published Date
Apr 15, 2020
Volume
6
Issue
16
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